1,3-Propanediol, 2-[(4-methoxyphenyl)methyl]-

Base Information

Chemical Name:1,3-Propanediol, 2-[(4-methoxyphenyl)methyl]-
CAS No.:63559-26-2
Molecular Formula:C11H16O3
Molecular Weight:196.246
Hs Code.:
DSSTox Substance ID:DTXSID40451698
Wikidata:Q82271853

Synonyms:63559-26-2;1,3-Propanediol, 2-[(4-methoxyphenyl)methyl]-;DTXSID40451698;2-(4-Methoxy-benzyl)-propane-1,3-diol

Suppliers and Price of 1,3-Propanediol, 2-[(4-methoxyphenyl)methyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1,3-Propanediol, 2-[(4-methoxyphenyl)methyl]-

Chemical Property:

XLogP3:1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:196.109944368
Heavy Atom Count:14
Complexity:138

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC=C(C=C1)CC(CO)CO

Technology Process of 1,3-Propanediol, 2-[(4-methoxyphenyl)methyl]-

There total 4 articles about 1,3-Propanediol, 2-[(4-methoxyphenyl)methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 6335-37-1
2-(4-methoxybenzyl)malonic acid diethyl ester

: 63559-26-2
2-(p-methoxybenzyl)propane-1,3-diol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; for 4h; Heating;
DOI:10.3987/COM-95-7232

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 63559-26-2
2-(p-methoxybenzyl)propane-1,3-diol

Guidance literature:: Multi-step reaction with 2 steps

1: 74 percent / 1.) sodium hydride / 1.) mineral oil, THF, r.t., 30 min; 2.) THF, 4 h, reflux

2: 95 percent / LiAlH₄ / tetrahydrofuran / 4 h / Heating

With lithium aluminium tetrahydride; sodium hydride; In tetrahydrofuran;
DOI:10.3987/COM-95-7232

Reference yield:

: 2746-25-0
p-Methoxybenzyl bromide

: 63559-26-2
2-(p-methoxybenzyl)propane-1,3-diol

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / 0 °C

1.2: 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / Cooling; Reflux

With lithium aluminium tetrahydride; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1002/adsc.201800956