1H-Indazole,5-bromo-7-ethyl-(9CI)

Base Information

• Chemical Name: 1H-Indazole,5-bromo-7-ethyl-(9CI)
• CAS No.: 635712-49-1
• Molecular Formula: C9H9BrN2
• Molecular Weight: 225.08500
• Hs Code.: 2933990090
• Mol file: 635712-49-1.mol

Synonyms:INDAZOLE,5-BROMO-7-ETHYL;1H-INDAZOLE,5-BROMO-7-ETHYL;

Chemical Property of 1H-Indazole,5-bromo-7-ethyl-(9CI)

Chemical Property:

• PSA: 28.68000
• LogP: 2.88780
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99.3% ^*data from raw suppliers

5-bromo-7-ethyl-1H-indazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Indazole,5-bromo-7-ethyl-(9CI)

There total 6 articles about 1H-Indazole,5-bromo-7-ethyl-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

4-Bromo-2-ethyl-6-methylphenyldiazo-t-butyl sulfide (943145-76-4) → 5-bromo-7-ethyl-1H-indazole (635712-49-1)

Guidance literature:

4-Bromo-2-ethyl-6-methylphenyldiazo-t-butyl sulfide; With potassium tert-butylate; In dimethyl sulfoxide; for 1h; Nitrogen atmosphere;

With hydrogenchloride; In water; dimethyl sulfoxide;

Reference yield: 79.2%

4-bromo-2-ethyl-6-methylphenylamine (70598-49-1) → 5-bromo-7-ethyl-1H-indazole (635712-49-1)

Guidance literature:

4-bromo-2-ethyl-6-methylphenylamine; With potassium acetate; acetic anhydride; In chloroform; at 0 - 20 ℃; for 1h; Inert atmosphere;

With tert.-butylnitrite; In chloroform; at 60 ℃;

Reference yield: 33.0%

4-bromo-2-ethyl-6-methylphenylamine (70598-49-1) → 5-bromo-7-ethyl-1H-indazole (635712-49-1) + 5-bromo-3,7-dimethyl-1H-indazole (1031417-71-6)

Guidance literature:

4-bromo-2-ethyl-6-methylphenylamine; With acetic acid; for 3h;

With sodium nitrite; at 20 ℃;

DOI:10.1021/jm201503u

upstream raw materials:

4-Bromo-2-ethyl-6-methylphenyldiazo-t-butyl sulfide

4-bromo-2-ethyl-6-methylphenylamine

6-ethyl-o-toluidine

Downstream raw materials:

C₂₁H₂₁N₃O₄

Refernces

• 1、 Han, Xiaojun,Civiello, Rita L.,Conway, Charles M.,Cook, Deborah A.,Davis, Carl D.,Degnan, Andrew P.,Jiang, Xiang-Jun,MacCi, Robert,Mathias, Neil R.,Moench, Paul,Pin, Sokhom S.,Schartman, Richard,Signor, Laura J.,Thalody, George,Tora, George,Whiterock, Valerie,Xu, Cen,MacOr, John E.,Dubowchik, Gene M.. "The synthesis and SAR of calcitonin gene-related peptide (CGRP) receptor antagonists derived from tyrosine surrogates. Part 2". . p. 1870 - 1873. Retrieved 2013/04/10.
• 2、 -. "SPIROKETONE ACETYL-COA CARBOXYLASE INHIBITORS". Page/Page column 31. . Retrieved 2008/12/06.