1-N-BOC-5-FORMYL-INDAZOLE

Base Information

• Chemical Name: 1-N-BOC-5-FORMYL-INDAZOLE
• CAS No.: 635713-71-2
• Molecular Formula: C13H14N2O3
• Molecular Weight: 246.266
• Hs Code.: 2933990090
• Mol file: 635713-71-2.mol

Synonyms:5-Formyl-indazole-1-carboxylic acid tert-butyl ester;Y9687;tert-Butyl 5-formyl-1H-indazole-1-carboxylate;5-Formyl-1H-indazole,N1-BOC protected;

Chemical Property of 1-N-BOC-5-FORMYL-INDAZOLE

Chemical Property:

• Vapor Pressure: 2.68E-06mmHg at 25°C
• Boiling Point: 390.3oC at 760 mmHg
• Flash Point: 189.8oC
• PSA: 61.19000
• Density: 1.2g/cm3
• LogP: 2.63200

Purity/Quality:

98% ^*data from raw suppliers

1-Boc-indazole-5-carboxaldehyde ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-N-BOC-5-FORMYL-INDAZOLE

There total 2 articles about 1-N-BOC-5-FORMYL-INDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1H-indazole-5-carbaldehyde (253801-04-6) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl 5-formyl-1H-indazole-1-carboxylate (635713-71-2)

Guidance literature:

dmap; In acetonitrile; at 20 ℃; for 0.5h;

Reference yield: 93.3%

→ tert-butyl 5-formyl-1H-indazole-1-carboxylate (635713-71-2)

Guidance literature:

With dmap; In dichloromethane; at 25 ℃; for 0.5h;

Reference yield: 85.0%

tert-butyl 5-formyl-1H-indazole-1-carboxylate (635713-71-2) + N-(benzyloxycarbonyl)-α-phosphonoglycine trimethyl ester → tert-butyl (Z)-5-(2-(benzyloxycarbonylamino)-3-methoxy-3-oxoprop-1-enyl)-1H-indazole-1-carboxylate (943145-64-0)

Guidance literature:

N-(benzyloxycarbonyl)-α-phosphonoglycine trimethyl ester; With N,N,N',N'-tetramethylguanidine; In tetrahydrofuran; at -78 ℃; for 0.333333h;

tert-butyl 5-formyl-1H-indazole-1-carboxylate; at -78 ℃; for 4.16667h;

upstream raw materials:

1H-indazole-5-carbaldehyde

di-tert-butyl dicarbonate

Downstream raw materials:

tert-butyl (Z)-5-(2-(benzyloxycarbonylamino)-3-methoxy-3-oxoprop-1-enyl)-1H-indazole-1-carboxylate

Refernces

• 1、 -. "GAMMA-DIKETONES AS WNT/BETA -CATENIN SIGNALING PATHWAY ACTIVATORS". Paragraph 1755; 1756; 1757; 1758; 1759. . Retrieved 2014/09/03.
• 2、 -. "HETEROARYLAMINO-PHENYLKETONE DERIVATIVES AND THEIR USE AS KINASE INHIBITORS". Page 37. . Retrieved 2010/02/10.