1-(5-CHLORO-2-METHYLPHENYL)-5-OXO-3-PYRROLIDINECARBOXYLIC ACID

Base Information

• Chemical Name: 1-(5-CHLORO-2-METHYLPHENYL)-5-OXO-3-PYRROLIDINECARBOXYLIC ACID
• CAS No.: 63675-00-3
• Molecular Formula: C12H12ClNO3
• Molecular Weight: 253.68200

Synonyms:1-(5-Chloro-2-methyl-phenyl)-5-oxo-pyrrolidine-3-carboxylic acid;

Chemical Property of 1-(5-CHLORO-2-METHYLPHENYL)-5-OXO-3-PYRROLIDINECARBOXYLIC ACID

Chemical Property:

• Melting Point: 136 - 137 °C
• PSA: 57.61000
• LogP: 2.15090

Purity/Quality:

97% ^*data from raw suppliers

1-(5-Chloro-2-methylphenyl)-5-oxopyrrolidine-3-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 36/37

MSDS Files:

Useful:

Technology Process of 1-(5-CHLORO-2-METHYLPHENYL)-5-OXO-3-PYRROLIDINECARBOXYLIC ACID

There total 1 articles about 1-(5-CHLORO-2-METHYLPHENYL)-5-OXO-3-PYRROLIDINECARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 1-(5-chloro-2-methyl-phenyl)-5-oxo-pyrrolidine-3-carboxylic acid (63675-00-3)

Guidance literature:

Itaconsaeure, entspr. Amin;

Reference yield: 94.0%

1-(5-chloro-2-methyl-phenyl)-5-oxo-pyrrolidine-3-carboxylic acid (63675-00-3) + 1,2-diamino-benzene (95-54-5) → 4-(1H-benzimidazol-2-yl)-1-(5-chloro-2-methylphenyl)pyrrolidin-2-one (890642-61-2)

Guidance literature:

With hydrogenchloride; In water; for 24h; Reflux;

DOI:10.1007/s11164-013-1067-6

Reference yield:

1-(5-chloro-2-methyl-phenyl)-5-oxo-pyrrolidine-3-carboxylic acid (63675-00-3) → 2-{2-[1-(5-choro-2-methylphenyl)-5-oxo-3-pyrrolidinyl]-1H-benzimidazol-1-yl}acetic acid (1423225-73-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: hydrogenchloride / water / 24 h / Reflux

2.1: potassium carbonate; potassium hydroxide; tetra-(n-butyl)ammonium iodide / toluene / 0.17 h

2.2: 5 h / Reflux

3.1: hydrogenchloride; water / 4 h / Reflux

4.1: sodium hydroxide / 0.02 h / Reflux

4.2: pH 6

With hydrogenchloride; water; tetra-(n-butyl)ammonium iodide; potassium carbonate; potassium hydroxide; sodium hydroxide; In water; toluene;

DOI:10.1007/s11164-013-1067-6

Downstream raw materials:

2-{2-[1-(5-choro-2-methylphenyl)-5-oxo-3-pyrrolidinyl]-1H-benzimidazol-1-yl}acetic acid

ethyl 2-{2-[1-(5-chloro-2-methylphenyl)-5-oxo-3-pyrrolidinyl]-1H-benzimidazol-1-yl}acetate

4-(1H-benzimidazol-2-yl)-1-(5-chloro-2-methylphenyl)pyrrolidin-2-one

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