Flutemetamol

Base Information

Chemical Name:Flutemetamol
CAS No.:637003-10-2
Molecular Formula:C14H11FN2OS
Molecular Weight:274.319
Hs Code.:
UNII:0F3M7032P5
Wikidata:Q27236700
NCI Thesaurus Code:C90868
Pharos Ligand ID:9TCAFJQJ88PU
Metabolomics Workbench ID:155260
ChEMBL ID:CHEMBL579205

Synonyms:(18F)flutemetamol;flutemetamol;flutemetamol F-18;Vizamyl

Suppliers and Price of Flutemetamol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Flutemetamol

Chemical Property:

XLogP3:3.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:274.05761231
Heavy Atom Count:19
Complexity:320

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CNC1=C(C=C(C=C1)C2=NC3=C(S2)C=C(C=C3)O)F
Recent ClinicalTrials:Longitudinal Study of Brain Amyloid imaGing in MEMENTO
Recent NIPH Clinical Trials:Clinical and neuroimaging study on preclinical Alzheimer's disease.

Technology Process of Flutemetamol

There total 4 articles about Flutemetamol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 2-fluoro-4-(6-methoxybenzo[d]thiazol-2-yl)-N-methylaniline

: 637003-10-2
2-(3-fluoro-4-(methylamino)phenyl)benzo[d]thiazol-6-ol

Guidance literature:: With boron tribromide; In dichloromethane; at 80 ℃; for 0.5h;
DOI:10.1021/jacs.7b03131

Reference yield:

: 213190-12-6
4-bromo-2-fluoro-N-methylaniline

: 637003-10-2
2-(3-fluoro-4-(methylamino)phenyl)benzo[d]thiazol-6-ol

Guidance literature:: Multi-step reaction with 3 steps

1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / toluene / 7 h / 90 °C / Inert atmosphere; Schlenk technique

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / water; N,N-dimethyl-formamide / 5 h / 80 °C / Inert atmosphere; Schlenk technique

3: boron tribromide / dichloromethane / 0.5 h / 80 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; boron tribromide; potassium carbonate; In dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jacs.7b03131

Reference yield:

: 367-24-8
4-bromo-2-fluoroaniline

: 637003-10-2
2-(3-fluoro-4-(methylamino)phenyl)benzo[d]thiazol-6-ol

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine; copper diacetate / 1,4-dioxane / 3 h / 20 - 90 °C

2: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / toluene / 7 h / 90 °C / Inert atmosphere; Schlenk technique

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / water; N,N-dimethyl-formamide / 5 h / 80 °C / Inert atmosphere; Schlenk technique

4: boron tribromide / dichloromethane / 0.5 h / 80 °C

With pyridine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; copper diacetate; boron tribromide; potassium carbonate; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jacs.7b03131