Technology Process of tert-butyl 6-oxa-2,9-diazaspiro[4.5]decane-9-carboxylate
There total 6 articles about tert-butyl 6-oxa-2,9-diazaspiro[4.5]decane-9-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
palladium 10% on activated carbon; ammonium formate;
In
methanol;
for 1h;
Reflux;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: ammonium hydroxide; water / methanol / 0 - 20 °C
2: triethylamine / dichloromethane / 5 h / 0 - 20 °C / Inert atmosphere
3: sodium hydride / mineral oil; tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere
4: lithium aluminium tetrahydride / tetrahydrofuran / 0.67 h / 0 °C / Reflux
5: sodium carbonate / water; tetrahydrofuran / 1 h / 0 °C
6: ammonium formate; palladium 10% on activated carbon / methanol / 1 h / Reflux
With
ammonium hydroxide; lithium aluminium tetrahydride; palladium 10% on activated carbon; water; ammonium formate; sodium hydride; sodium carbonate; triethylamine;
In
tetrahydrofuran; methanol; dichloromethane; water; mineral oil;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: triethylamine / dichloromethane / 5 h / 0 - 20 °C / Inert atmosphere
2: sodium hydride / mineral oil; tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere
3: lithium aluminium tetrahydride / tetrahydrofuran / 0.67 h / 0 °C / Reflux
4: sodium carbonate / water; tetrahydrofuran / 1 h / 0 °C
5: ammonium formate; palladium 10% on activated carbon / methanol / 1 h / Reflux
With
lithium aluminium tetrahydride; palladium 10% on activated carbon; ammonium formate; sodium hydride; sodium carbonate; triethylamine;
In
tetrahydrofuran; methanol; dichloromethane; water; mineral oil;