methyl 2,4-dioxo-1H-3,1-benzoxazine-6-carboxylate

Base Information

Chemical Name:methyl 2,4-dioxo-1H-3,1-benzoxazine-6-carboxylate
CAS No.:63746-26-9
Molecular Formula:C10H7NO5
Molecular Weight:221.169
Hs Code.:
DSSTox Substance ID:DTXSID401179971
Nikkaji Number:J3.336.475J
Wikidata:Q107914305

Synonyms:63746-26-9;SCHEMBL5534473;DTXSID401179971;Methyl 1,4-dihydro-2,4-dioxo-2H-3,1-benzoxazine-6-carboxylate;Methyl 2,4-dioxo-1,4-dihydro-2H-benzo[d][1,3]oxazine-6-carboxylate

Suppliers and Price of methyl 2,4-dioxo-1H-3,1-benzoxazine-6-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 2,4-dioxo-1H-3,1-benzoxazine-6-carboxylate

Chemical Property:

XLogP3:0.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:221.03242232
Heavy Atom Count:16
Complexity:340

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)C1=CC2=C(C=C1)NC(=O)OC2=O

Technology Process of methyl 2,4-dioxo-1H-3,1-benzoxazine-6-carboxylate

There total 1 articles about methyl 2,4-dioxo-1H-3,1-benzoxazine-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4315-09-7
4-nitroisophthalic acid

: 63746-26-9
methyl 2,4-dioxo-2,4-dihydro-1H-benzo[d][1,3]oxazine-6-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sulfuric acid / methanol / 4 h / Reflux

2: hydrogen / palladium 10% on activated carbon / methanol / 20 h

3: tetrahydrofuran / 24 h / Reflux

With sulfuric acid; hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; methanol;

Reference yield:

: 7305-71-7
5-methyl-2-thiazol-2-amine

: 63746-26-9
methyl 2,4-dioxo-2,4-dihydro-1H-benzo[d][1,3]oxazine-6-carboxylate

: 1374779-84-6
C₁₃H₁₃N₃O₃S

Guidance literature:: dmap; In N,N-dimethyl-formamide; at 70 - 80 ℃; for 10h;

Reference yield:

: 63746-26-9
methyl 2,4-dioxo-2,4-dihydro-1H-benzo[d][1,3]oxazine-6-carboxylate

: 1374778-43-4
4-(3-chlorobenzo[b]thiophene-2-carboxamido)-3-(5-methylthiazol-2-ylcarbamoyl)benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: dmap / N,N-dimethyl-formamide / 10 h / 70 - 80 °C

2: tetrahydrofuran / 12 h / Reflux

3: water; lithium hydroxide / tetrahydrofuran / 20 °C

With water; lithium hydroxide; dmap; In tetrahydrofuran; N,N-dimethyl-formamide;