PROTEIN C

Base Information

• Chemical Name: PROTEIN C
• CAS No.: 42617-41-4
• Molecular Weight: 0
• Mol file: 42617-41-4.mol

Synonyms:

Chemical Property of PROTEIN C

Chemical Property:

• Storage Temp.: −20°C
• Solubility.: H2O: 1 mg/mL

Purity/Quality:

98%,99%, ^*data from raw suppliers

Protein C ^*data from reagent suppliers

Safty Information:

• Hazard Codes: B
• Statements: 36/37
• Safety Statements: 36/37-36-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Description: Drotrecogin alfa was introduced in the US as a new intravenous treatment for the reduction of mortality in adult patients with severe sepsis associated with acute organ dysfunction. Drotrecogin aifa is the first recombinant activated protein C expressed in human kidney 293 cells. Activated protein C1 an endogenous serine protease, acts as an antithrombotic via inhibition of factor Va and Vllla, promotes fibrinolysis via inactivation of plasminogen-activator inhibitor-1 and exerts an anti-inflammatory effect by inhibiting the production of inflammatory cytokines (tumor necrosis factor-alpha, interieukin-1 and 6) by monocytes. It was shown that the majority of patients with sepsis have reduced levels of activated protein C. In a baboon model of lethal E. coli sepsis, administration of activated protein C reduced mortality. In a phase III clinical trial, intravenous infusion of drotrecogin alfa at a dose of 24 μg/kg/h over 96 h significantly reduced the risk of death compared with placebo in patients with severe sepsis. However, an increased risk of serious bleeding has been associated with the administration of the drug.
• Uses: Protein C from human plasma has been used for pre-treatment of endothelial cells prior to antibody-inhibition assay. It has also been used in activated protein C (APC) assay to determine its inhibitory effect on copper.