NSC 663284

Base Information

• Chemical Name: NSC 663284
• CAS No.: 383907-43-5
• Molecular Formula: C15H16ClN3O3
• Molecular Weight: 321.7588
• Mol file: 383907-43-5.mol

Synonyms:6-Chloro-7-(2-morpholin-4-yl-ethylamino)quinoline-5,8-dione;DA3003-1;

Chemical Property of NSC 663284

Chemical Property:

• Vapor Pressure: 2.49E-09mmHg at 25°C
• Boiling Point: 478.8°Cat760mmHg
• PKA: 6.79±0.10(Predicted)
• Flash Point: 243.4°C
• PSA: 71.53000
• Density: 1.41g/cm³
• LogP: 1.16160
• Storage Temp.: 2-8°C
• Sensitive.: Light Sensitive
• Solubility.: DMSO: 16 mg/mL

Purity/Quality:

97% ^*data from raw suppliers

NSC 663284 ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Description: NSC663284 (383907-43-5) is a potent, selective and irreversible inhibitor of CDC25 phosphatases, Ki=29, 95 and 89 nM for human CDC25A, B2 and C respectively and >20- and >450-fold selective over VHR and PTP1B.1?Arrests cells at G1 and G2/M and inhibits cdk1 and 2 activation.2 Inhibits the growth of a variety of human tumor cell lines.3 NSC663284 acts via irreversible oxidation of the catalytic cysteine of CDC25.4
• Uses: CDC25 Phosphatase Inhibitor II, NSC 663284 is a competitive CDC25 inhibitor and cell cycle arresting compound.

Technology Process of NSC 663284

There total 1 articles about NSC 663284 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(2-AMINOETHYL)MORPHOLINE (2038-03-1) + 6,7-dichloroquinoline-5,8-dione (6541-19-1) → 6-chloro-7-((2-morpholin-4-yl)ethylamino)quinoline-5,8-dione (383907-43-5) + DA 3003-2

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 20h;

DOI:10.1021/jm0102046

upstream raw materials:

4-(2-AMINOETHYL)MORPHOLINE

6,7-dichloroquinoline-5,8-dione