4-(3-METHYLPHENOXY)PIPERIDINE

Base Information

• Chemical Name: 4-(3-METHYLPHENOXY)PIPERIDINE
• CAS No.: 63843-46-9
• Molecular Formula: C12H17NO
• Molecular Weight: 191.273
• Hs Code.: 2933399090
• Mol file: 63843-46-9.mol

Synonyms:4-m-tolyloxy-piperidine;

Chemical Property of 4-(3-METHYLPHENOXY)PIPERIDINE

Chemical Property:

• Vapor Pressure: 0.00102mmHg at 25°C
• Melting Point: 190-191℃
• Boiling Point: 302oC at 760 mmHg
• Flash Point: 121.8oC
• PSA: 21.26000
• Density: 1.016g/cm3
• LogP: 2.45460

Purity/Quality:

99% ^*data from raw suppliers

4-(3-Methylphenoxy)piperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-(3-Methylphenoxy)piperidine is used as pharmaceutical intermediate.

Technology Process of 4-(3-METHYLPHENOXY)PIPERIDINE

There total 1 articles about 4-(3-METHYLPHENOXY)PIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 4-(3-methylphenoxy)piperidine (63843-46-9)

Guidance literature:

1-Benzyl-4-(3-tolyloxy)-piperidin, H2/Pd/C;

DOI:10.1021/jm00201a018

Reference yield: 70.0%

4-(3-methylphenoxy)piperidine (63843-46-9) + trans-(2-isocyanatocyclopropyl)benzene (35019-96-6,63006-15-5,63009-74-5,79082-68-1) → 4-(3-methylphenoxy)-N-[(1SR,2RS)-2-phenylcyclopropyl]piperidine-1-carboxamide

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In toluene; at 20 ℃; for 12h;

DOI:10.1016/j.bmc.2014.01.040

Reference yield: 44.0%

4-chloro-1,6-dimethyl-2-oxo-1,2-dihydroquinoline-3-carbonitrile + 4-(3-methylphenoxy)piperidine (63843-46-9) → 1,6-dimethyl-4-[4-(3-methylphenoxy)piperidin-1-yl]-2-oxo-1,2-dihydroquinoline-3-carbonitrile

Guidance literature:

With triethylamine; In isopropyl alcohol; at 90 ℃; for 4h;

Refernces

• 1、 -. "Method of treating pain and hypertension". . . Retrieved 2008/06/13.