4,5-Dihydro-5-methyl-6-(4-(methylamino)-7-quinazolinyl)-3(2H)-pyridazinone

Base Information

Chemical Name:4,5-Dihydro-5-methyl-6-(4-(methylamino)-7-quinazolinyl)-3(2H)-pyridazinone
CAS No.:124294-25-3
Molecular Formula:C₁₄H₁₅N₅O
Molecular Weight:269.306
Hs Code.:
DSSTox Substance ID:DTXSID20924774
Nikkaji Number:J412.261E
Mol file:124294-25-3.mol

Synonyms:4,5-Dihydro-5-methyl-6-(4-(methylamino)-7-quinazolinyl)-3(2H)-pyridazinone;124294-25-3;3(2H)-Pyridazinone, 4,5-dihydro-5-methyl-6-(4-(methylamino)-7-quinazolinyl)-;SCHEMBL7266756;DTXSID20924774;LS-129907;4,5-Dihydro-5-methyl-6-(4-methylaminoquinazolin-7-yl)pyridazin-3(2H)-one;5-Methyl-6-[4-(methylimino)-3,4-dihydroquinazolin-7-yl]-4,5-dihydropyridazin-3-ol

Suppliers and Price of 4,5-Dihydro-5-methyl-6-(4-(methylamino)-7-quinazolinyl)-3(2H)-pyridazinone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 4,5-Dihydro-5-methyl-6-(4-(methylamino)-7-quinazolinyl)-3(2H)-pyridazinone

Chemical Property:

Refractive Index:1.713
Boiling Point:°Cat760mmHg
Flash Point:°C
Density:1.4g/cm³
XLogP3:1.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:269.12766012
Heavy Atom Count:20
Complexity:410

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1CC(=O)NN=C1C2=CC3=C(C=C2)C(=NC=N3)NC

Technology Process of 4,5-Dihydro-5-methyl-6-(4-(methylamino)-7-quinazolinyl)-3(2H)-pyridazinone

There total 7 articles about 4,5-Dihydro-5-methyl-6-(4-(methylamino)-7-quinazolinyl)-3(2H)-pyridazinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 124294-13-9
3,4-Dihydro-4-imino-3-methyl-7-(2,3,4,5-tetrahydro-5-methyl-3-oxo-6-pyridazinyl)quinazoline

: 124294-25-3
4,5-dihydro-5-methyl-6-(methylamino-7-quinazolinyl)-3(2H)-pyridazinone

Guidance literature:: With sodium hydroxide; at 100 ℃; for 5h;
DOI:10.1248/cpb.39.352

Reference yield:

: 124294-91-3
4,5-Dihydro-6-(3-amino-4-cyanophenyl)-5-methyl-3(2H)-pyridazinone

: 124294-25-3
4,5-dihydro-5-methyl-6-(methylamino-7-quinazolinyl)-3(2H)-pyridazinone

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / CF₃COOH / 1 h / 80 °C

2: 63 percent / methanol / 0.5 h / 50 °C

3: 76 percent / 2N NaOH / 5 h / 100 °C

With sodium hydroxide; trifluoroacetic acid; In methanol;
DOI:10.1248/cpb.39.352

Reference yield:

: 124294-88-8
(+/-)-4-(4-bromo-3-nitrophenyl)-3-methyl-4-oxobutyric acid

: 124294-25-3
4,5-dihydro-5-methyl-6-(methylamino-7-quinazolinyl)-3(2H)-pyridazinone

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / hydrazine hydrate / acetic acid / 3 h / 100 °C

2: 58 percent / dimethylformamide / 2.5 h / 100 °C

3: 67 percent / SnCl₂*2H₂O; conc. HCl / dimethylformamide / 0.5 h / 5 - 10 °C

4: 82 percent / CF₃COOH / 1 h / 80 °C

5: 63 percent / methanol / 0.5 h / 50 °C

6: 76 percent / 2N NaOH / 5 h / 100 °C

With hydrogenchloride; sodium hydroxide; hydrazine hydrate; trifluoroacetic acid; tin(ll) chloride; In methanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1248/cpb.39.352