4-(2-Chlorothieno[2,3-d]pyrimidin-4-yl)morpholine

Base Information

• Chemical Name: 4-(2-Chlorothieno[2,3-d]pyrimidin-4-yl)morpholine
• CAS No.: 63894-67-7
• Molecular Formula: C10H10ClN3OS
• Molecular Weight: 255.72400
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID40516014
• Wikidata: Q82377217
• Mol file: 63894-67-7.mol

Synonyms:4-(2-chlorothieno[2,3-d]pyrimidin-4-yl)morpholine;63894-67-7;2-Chloro-4-morpholinothieno[2,3-d]pyrimidine;4-{2-chlorothieno[2,3-d]pyrimidin-4-yl}morpholine;SCHEMBL190563;DTXSID40516014;YPVVQAPITTYKRL-UHFFFAOYSA-N;MFCD15144569;AKOS015919514;DS-14658;CS-0155511;A23318;EN300-343168;2-Chloro-4-(4-morpholinyl)thieno[2,3-d]pyrimidine;2-Chloro-4-morpholin-4-yl-thieno[2,3-d]pyrimidine;2-Chloro-4-(morpholin-4-yl)thieno[2,3-d]pyrimidine;4-(2-Chlorothieno[2 pound not3-d]pyrimidin-4-yl)morpholine

Chemical Property of 4-(2-Chlorothieno[2,3-d]pyrimidin-4-yl)morpholine

Chemical Property:

• PSA: 66.49000
• LogP: 2.24630
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 1
• Exact Mass: 255.0233108
• Heavy Atom Count: 16
• Complexity: 252

Purity/Quality:

97% ^*data from raw suppliers

4-(2-Chlorothieno[2,3-d]pyrimidin-4-yl)morpholine 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCN1C2=C3C=CSC3=NC(=N2)Cl

Technology Process of 4-(2-Chlorothieno[2,3-d]pyrimidin-4-yl)morpholine

There total 5 articles about 4-(2-Chlorothieno[2,3-d]pyrimidin-4-yl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.4%

morpholine (110-91-8,99108-56-2) + 2,4-dichlorothieno[2,3-d]pyrimidine (18740-39-1) → 4-(2-chlorothiophen[2,3-d]pyrimidin-4-yl)morpholine (63894-67-7)

Guidance literature:

morpholine; 2,4-dichlorothieno[2,3-d]pyrimidine; In methanol; at 20 ℃; for 1 - 2h;

With water; In methanol; at 25 ℃;

Reference yield:

Methyl 2-aminothiophene-3-carboxylate (4651-81-4) → 4-(2-chlorothiophen[2,3-d]pyrimidin-4-yl)morpholine (63894-67-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: dichloromethane / -60 - 20 °C / Inert atmosphere

2.1: water; sodium hydroxide / 0.33 h / 85 °C

2.2: 18 h / 20 °C / pH 1

3.1: trichlorophosphate / acetonitrile / 24 h / Reflux

4.1: ethanol / 20 °C

With water; sodium hydroxide; trichlorophosphate; In ethanol; dichloromethane; acetonitrile;

DOI:10.1021/jm2007084

Reference yield:

1H-thieno[2,3-d]pyrimidine-2,4-dione (18740-38-0) → 4-(2-chlorothiophen[2,3-d]pyrimidin-4-yl)morpholine (63894-67-7)

Guidance literature:

Multi-step reaction with 2 steps

1: trichlorophosphate / acetonitrile / 24 h / Reflux

2: ethanol / 20 °C

With trichlorophosphate; In ethanol; acetonitrile;

DOI:10.1021/jm2007084

upstream raw materials:

morpholine

2,4-dichlorothieno[2,3-d]pyrimidine

Methyl 2-aminothiophene-3-carboxylate

1H-thieno[2,3-d]pyrimidine-2,4-dione

Downstream raw materials:

4-(2-chloro-6-(3-(methylsulfonyl)phenyl)thieno[2,3-d ]pyrimidin-4-yl)morpholine

5-(6-(3-(methylsulfonyl)phenyl)-4-morpholinothieno[2,3-d]-pyrimidin-2-yl)pyrimidin-2-amine