(7-Chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-ylidene)-N-methylacetamide

Base Information

Chemical Name:(7-Chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-ylidene)-N-methylacetamide
CAS No.:112634-61-4
Molecular Formula:C₁₈H₁₅ClFN₃O
Molecular Weight:343.788
Hs Code.:

Synonyms:BRN 5125777;(7-Chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-ylidene)-N-methylacetamide;Acetamide, 2-(7-chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-ylidene)-N-methyl-;112634-61-4;C18H15ClFN3O;C18-H15-Cl-F-N3-O;LS-8554

Suppliers and Price of (7-Chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-ylidene)-N-methylacetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (7-Chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-ylidene)-N-methylacetamide

Chemical Property:

Vapor Pressure:3.17E-11mmHg at 25°C
Boiling Point:527.7°Cat760mmHg
Flash Point:273°C
Density:1.32g/cm³
XLogP3:3.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:343.0887680
Heavy Atom Count:24
Complexity:536

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CNC(=O)C=C1CN=C(C2=C(N1)C=CC(=C2)Cl)C3=CC=CC=C3F
Isomeric SMILES:CNC(=O)/C=C/1\CN=C(C2=C(N1)C=CC(=C2)Cl)C3=CC=CC=C3F

Technology Process of (7-Chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-ylidene)-N-methylacetamide

There total 3 articles about (7-Chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-ylidene)-N-methylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 112634-54-5
7-chloro-2,3-dihydro-5-(2-fluorophenyl)-N-methyl-1H-1,4-benzodiazepine-2-acetamide

: 112634-61-4
<7-chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-ylidene>-N-methylamide

Guidance literature:: With manganese(IV) oxide; In 1,2-dichloro-ethane; for 3h; Heating;
DOI:10.1002/jhet.5570240327

Reference yield:

: 112634-51-2
7-chloro-2,3-dihydro-5-(2-fluorophenyl)-1H-1,4-benzodiazepine-2-acetic acid methyl ester

: 112634-61-4
<7-chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-ylidene>-N-methylamide

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / methanol / 3 h / 100 °C / in a steel bomb

2: 25 percent / act. MnO₂ / 1,2-dichloro-ethane / 3 h / Heating

With manganese(IV) oxide; In methanol; 1,2-dichloro-ethane;
DOI:10.1002/jhet.5570240327

Reference yield:

: 59468-40-5
7-chloro-1,3-dihydro-5-(2-fluorophenyl)-2H-1,4-benzodiazepin-2-ylidene acetic acid methyl ester

: 112634-61-4
<7-chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-ylidene>-N-methylamide

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / triethylsilane / trifluoroacetic acid / 0.5 h

2: 78 percent / methanol / 3 h / 100 °C / in a steel bomb

3: 25 percent / act. MnO₂ / 1,2-dichloro-ethane / 3 h / Heating

With triethylsilane; manganese(IV) oxide; In methanol; 1,2-dichloro-ethane; trifluoroacetic acid;
DOI:10.1002/jhet.5570240327