3,4-Furandimethanol

Base Information

• Chemical Name: 3,4-Furandimethanol
• CAS No.: 14496-24-3
• Molecular Formula: C6H8 O3
• Molecular Weight: 128.128
• Hs Code.: 2932190090
• European Community (EC) Number: 238-505-5
• UNII: L8MK9B9DQV
• DSSTox Substance ID: DTXSID50162849
• Nikkaji Number: J236.721A
• Wikidata: Q83031607
• Mol file: 14496-24-3.mol

Synonyms:3,4-Furandimethanol;14496-24-3;Furan-3,4-diyldimethanol;3,4-Bis(hydroxymethyl)furan;[4-(hydroxymethyl)furan-3-yl]methanol;EINECS 238-505-5;L8MK9B9DQV;UNII-L8MK9B9DQV;SCHEMBL4651248;DTXSID50162849;3,4-Bis(hydroxymethyl)furan, 98%

Chemical Property of 3,4-Furandimethanol

Chemical Property:

• Vapor Pressure: 5.21mmHg at 25°C
• Boiling Point: 137.4°C at 760 mmHg
• PKA: 13.88±0.10(Predicted)
• Flash Point: 36.9°C
• PSA: 53.60000
• Density: 1.248 g/mL at 25 °C
• LogP: 0.26420
• XLogP3: -0.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 128.047344113
• Heavy Atom Count: 9
• Complexity: 74.4

Purity/Quality:

98%,99%, ^*data from raw suppliers

3,4-Furandimethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C(=CO1)CO)CO
• Uses: 3,4-Furandimethanol has been used as a reactant in the preparation of N-[(benzimidazolyl)methyl]aminotetrahydroquinoline derivatives as CXCR4 antagonists that are potent inhibitors of T tropic (X4) HIV-1 replication.

Technology Process of 3,4-Furandimethanol

There total 6 articles about 3,4-Furandimethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

dimethyl 3,4-furandicarboxylate (4282-33-1) → 3,4-bis(hydroxymethyl)furan (14496-24-3)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 0 - 20 ℃;

DOI:10.1021/ol0101281

Reference yield: 77.0%

diethyl 3,4-furandicarboxylate (30614-77-8) → 3,4-bis(hydroxymethyl)furan (14496-24-3)

Guidance literature:

With lithium aluminium tetrahydride;

DOI:10.1016/S0040-4039(00)85880-3

Reference yield:

4-methyloxazole (693-93-6) + 1,4-dihydroxybut-2-yne (110-65-6) → 3,4-bis(hydroxymethyl)furan (14496-24-3)

Guidance literature:

With hydroquinone; at 170 ℃; for 24h;

upstream raw materials:

dimethyl 3,4-furandicarboxylate

diethyl 3,4-furandicarboxylate

4-methyloxazole

1,4-dihydroxybut-2-yne

Downstream raw materials:

3-benzyloxymethyl-4-furanmethanol

3,4-bis(benzyloxymethyl)furan

Refernces

• 1、 Clark, J. Stephen,Marlin, Frederic,Nay, Bastien,Wilson, Claire. "Synthesis of the carbocyclic core of the cornexistins by ring-closing metathesis". . p. 89 - 92. Retrieved 2003.
• 2、 McElhanon, James R.,Wheeler, David R.. "Thermally responsive dendrons and dendrimers based on reversible furan-maleimide diels-alder adducts". . p. 2681 - 2683. Retrieved 2007/10/03.