4-(Diethoxyphosphorylmethyl)-2-methyl-1,3-thiazole

Base Information

Chemical Name:4-(Diethoxyphosphorylmethyl)-2-methyl-1,3-thiazole
CAS No.:63928-37-0
Molecular Formula:C9H16NO3PS
Molecular Weight:249.271
Hs Code.:2934100090
DSSTox Substance ID:DTXSID10376804
Nikkaji Number:J1.109.313B
Wikidata:Q82165720
Mol file:63928-37-0.mol

Synonyms:Diethyl 2-methylthiazole-4-methylphosphonate;63928-37-0;4-(diethoxyphosphorylmethyl)-2-methyl-1,3-thiazole;Diethyl ((2-methylthiazol-4-yl)methyl)phosphonate;diethyl [(2-methyl-1,3-thiazol-4-yl)methyl]phosphonate;SCHEMBL1107431;DTXSID10376804;HEMJMIICMXSNBL-UHFFFAOYSA-N;AKOS015949400;FT-0685291;Diethyl((2-methylthiazol-4-yl)methyl)phosphonate;J-520289;2-Methyl-4-thiazolylmethylphosphonic acid diethyl ester;Diethyl (2-methyl-1,3-thiazol-4-yl)-methylphosphonate

Suppliers and Price of 4-(Diethoxyphosphorylmethyl)-2-methyl-1,3-thiazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
Diethyl 2-methylthiazole-4-methylphosphonate 97%
500mg
$ 719.00

Crysdot
Diethyl((2-methylthiazol-4-yl)methyl)phosphonate 95+%
1g
$ 756.00

Alichem
Diethyl((2-methylthiazol-4-yl)methyl)phosphonate
1g
$ 764.00

AK Scientific
Diethyl2-methylthiazole-4-methylphosphonate
500mg
$ 1020.00

Total 4 raw suppliers

Chemical Property of 4-(Diethoxyphosphorylmethyl)-2-methyl-1,3-thiazole

Chemical Property:

Vapor Pressure:7.03E-05mmHg at 25°C
Boiling Point:354oC at 760 mmHg
Flash Point:167.9oC
PSA：86.47000
Density:1.2g/cm3
LogP:3.21760
XLogP3:1.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:249.05885154
Heavy Atom Count:15
Complexity:229

Purity/Quality:

98%min ^*data from raw suppliers

Diethyl 2-methylthiazole-4-methylphosphonate 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOP(=O)(CC1=CSC(=N1)C)OCC

Technology Process of 4-(Diethoxyphosphorylmethyl)-2-methyl-1,3-thiazole

There total 1 articles about 4-(Diethoxyphosphorylmethyl)-2-methyl-1,3-thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6436-59-5
ethyl 2-methylthiazole-4-carboxylate

: 63928-37-0
diethyl (2-methyl-1,3-thiazol-4-yl)methylphosphonate

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / LiAlH₄ / diethyl ether / 3 h / -78 °C

2: 85 percent / Ph₃P; CBr₄ / CCl₄ / 3 h / 20 °C

3: 86 percent / 3 h / 160 °C

With lithium aluminium tetrahydride; carbon tetrabromide; triphenylphosphine; In tetrachloromethane; diethyl ether;
DOI:10.1021/jo048742o

Reference yield: 99.0%

: 924961-40-0
(3S)-3-[(2R,3S)-3-tert-butyldiphenylsiloxy-4,4-dimethyloxolan-2-yl]oxy-5-hexen-2-one

: 63928-37-0
diethyl (2-methyl-1,3-thiazol-4-yl)methylphosphonate

: 924961-41-1
(3S)-3-[(2R,3S)-3-tert-butyldiphenylsiloxy-4,4-dimethyloxolan-2-yloxy]-2-methyl-1-(2-methyl-1,3-thiazol-4-yl)hexa-(1E,5)-diene

Guidance literature:: diethyl (2-methyl-1,3-thiazol-4-yl)methylphosphonate; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.5h;

(3S)-3-[(2R,3S)-3-tert-butyldiphenylsiloxy-4,4-dimethyloxolan-2-yl]oxy-5-hexen-2-one; at 20 ℃; for 15h;
DOI:10.1021/jo0618573

Reference yield: 83.0%

: 220351-95-1
(3S)-5-[[Dimethyl(1,1-dimethylethyl)silyl] oxy]-3-[[(1,1-dimethylethyl)diphenylsilyl] oxy]-2-pentanone

: 63928-37-0
diethyl (2-methyl-1,3-thiazol-4-yl)methylphosphonate

: 220352-31-8
(E,3S)-1-[[Dimethyl(1,1-dimethylethyl)silyl]oxy]-3-[[(1,1-dimethylethyl)diphenylsilyl] oxy]-4-methyl-5-(2-methylthiazol-4-yl)-pent-4-ene

Guidance literature:: diethyl (2-methyl-1,3-thiazol-4-yl)methylphosphonate; With n-butyllithium; In tetrahydrofuran; hexane; at -5 - 23 ℃; for 2h;

(3S)-5-[[Dimethyl(1,1-dimethylethyl)silyl] oxy]-3-[[(1,1-dimethylethyl)diphenylsilyl] oxy]-2-pentanone; In tetrahydrofuran; hexane; at -78 - 23 ℃; for 16h;