(R)-3-(benzyloxy)-2-methylpropan-1-ol

Base Information

• Chemical Name: (R)-3-(benzyloxy)-2-methylpropan-1-ol
• CAS No.: 63930-49-4
• Molecular Formula: C11H16O2
• Molecular Weight: 180.247
• DSSTox Substance ID: DTXSID30456132
• Nikkaji Number: J408.215J
• Wikidata: Q82278354
• Mol file: 63930-49-4.mol

Synonyms:(R)-3-(benzyloxy)-2-methylpropan-1-ol;63930-49-4;(R)-2-BENZYLOXYMETHYL-PROPANOL;SCHEMBL4545487;DTXSID30456132;NGRZOWQXYGMVQS-SNVBAGLBSA-N;MFCD17926175;(R)-2-(Benzyloxymethyl)-1-propanol;(2R)-2-methyl-3-phenylmethoxypropan-1-ol;CS-0199774;A914936

Chemical Property of (R)-3-(benzyloxy)-2-methylpropan-1-ol

Chemical Property:

• XLogP3: 1.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 180.115029749
• Heavy Atom Count: 13
• Complexity: 119

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(CO)COCC1=CC=CC=C1
• Isomeric SMILES: C[C@H](CO)COCC1=CC=CC=C1

Technology Process of (R)-3-(benzyloxy)-2-methylpropan-1-ol

There total 67 articles about (R)-3-(benzyloxy)-2-methylpropan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl (S)-3-benzyloxy-2-methylpropanoate (74924-27-9) → (R)-3-(benzyloxy)-2-methylpropan-1-ol (63930-49-4)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 1h;

DOI:10.1016/S0040-4020(01)81722-1

Reference yield: 96.0%

(R)-4-Benzyl-3-((S)-3-benzyloxy-2-methyl-propionyl)-oxazolidin-2-one (203454-44-8) → (R)-3-(benzyloxy)-2-methylpropan-1-ol (63930-49-4)

Guidance literature:

With methanol; lithium borohydride; In tetrahydrofuran; for 6h;

DOI:10.1002/anie.200603353

Reference yield: 95.0%

Benzyloxymethyl chloride (3587-60-8) + (3R)-3-propionyl-4-benzyloxazolidin-2-one (101711-78-8,131685-53-5) → (R)-3-(benzyloxy)-2-methylpropan-1-ol (63930-49-4)

Guidance literature:

Benzyloxymethyl chloride; (3R)-3-propionyl-4-benzyloxazolidin-2-one; With titanium tetrachloride; N-ethyl-N,N-diisopropylamine; In dichloromethane;

With sodium tetrahydroborate; In tetrahydrofuran; water; Further stages.;

DOI:10.1021/ol991345t

upstream raw materials:

((2-methylallyloxy)methyl)benzene

Benzyl 3-(phenylmethoxy)-2-methylpropanoate

2-methyl-1.3-propanediol

benzyl bromide

Downstream raw materials:

(S)-3-benzyloxy-2-methylpropan-1-ol

(S)-3-benzyloxy-2-methylpropyl acetate

(R)-3-benzyloxy-2-methylpropyl acetate

(S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid 3-benzyloxy-2-methyl-propyl ester