4-{[5-(3-hydroxy-4-methoxybenzyl)-4-(4-methoxybenzyl)-1-methyl-1H-imidazol-2-yl]amino}-1-methyl-1H-imidazole-2,5-dione

Base Information

Chemical Name:4-{[5-(3-hydroxy-4-methoxybenzyl)-4-(4-methoxybenzyl)-1-methyl-1H-imidazol-2-yl]amino}-1-methyl-1H-imidazole-2,5-dione
CAS No.:121819-68-9
Molecular Formula:C₂₄H₂₅N₅O₅
Molecular Weight:463.493
Hs Code.:

Synonyms:Naamidine B

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-{[5-(3-hydroxy-4-methoxybenzyl)-4-(4-methoxybenzyl)-1-methyl-1H-imidazol-2-yl]amino}-1-methyl-1H-imidazole-2,5-dione

Chemical Property:

Vapor Pressure:1.27E-17mmHg at 25°C
Boiling Point:652.4°Cat760mmHg
Flash Point:348.3°C
Density:1.35g/cm³

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-{[5-(3-hydroxy-4-methoxybenzyl)-4-(4-methoxybenzyl)-1-methyl-1H-imidazol-2-yl]amino}-1-methyl-1H-imidazole-2,5-dione

There total 14 articles about 4-{[5-(3-hydroxy-4-methoxybenzyl)-4-(4-methoxybenzyl)-1-methyl-1H-imidazol-2-yl]amino}-1-methyl-1H-imidazole-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: C₂₀H₂₃N₃O₃

: 546113-06-8
1-methyl-3-trimethylsilylparabanic acid

: 121819-68-9
naamidine B

Guidance literature:: In toluene; for 18h; Reflux;
DOI:10.3390/md16090311

Reference yield:

: 2-acetamido-3-(3-(benzyloxy)-4-methoxyphenyl)propanoic acid

: 121819-68-9
naamidine B

Guidance literature:: Multi-step reaction with 10 steps

1.1: hydrogenchloride / 24 h / Reflux

2.1: triethylamine / water; 1,4-dioxane / 18 h / 20 °C

3.1: potassium carbonate / methanol / 4 h / Reflux

4.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

4.2: 24 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 20 °C

6.1: magnesium / tetrahydrofuran; diethyl ether / 1 h / 0 - 20 °C / Inert atmosphere

6.2: 3 h / 0 - 20 °C / Inert atmosphere

7.1: acetyl chloride / ethanol; diethyl ether / 1.17 h / -30 - 20 °C

8.1: water / 1 h / 90 °C

9.1: palladium 10% on activated carbon; hydrogen / methanol; acetic acid / 24 h / 20 °C

10.1: toluene / 18 h / Reflux

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; sodium hydride; potassium carbonate; benzotriazol-1-ol; magnesium; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; acetyl chloride; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; ethanol; dichloromethane; water; acetic acid; toluene;
DOI:10.3390/md16090311

Reference yield:

: 3-(3-(benzyloxy)-4-methoxyphenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid

: 121819-68-9
naamidine B

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

1.2: 24 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 20 °C

3.1: magnesium / tetrahydrofuran; diethyl ether / 1 h / 0 - 20 °C / Inert atmosphere

3.2: 3 h / 0 - 20 °C / Inert atmosphere

4.1: acetyl chloride / ethanol; diethyl ether / 1.17 h / -30 - 20 °C

5.1: water / 1 h / 90 °C

6.1: palladium 10% on activated carbon; hydrogen / methanol; acetic acid / 24 h / 20 °C

7.1: toluene / 18 h / Reflux

With palladium 10% on activated carbon; hydrogen; sodium hydride; benzotriazol-1-ol; magnesium; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; acetyl chloride; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; water; acetic acid; toluene;
DOI:10.3390/md16090311