N-(Bis(4-methoxyphenyl)methyl)-N2-((phenylmethoxy)carbonyl)-L-glutamine

Base Information

• Chemical Name: N-(Bis(4-methoxyphenyl)methyl)-N2-((phenylmethoxy)carbonyl)-L-glutamine
• CAS No.: 28252-49-5
• Molecular Formula: C28H30 N2 O7
• Molecular Weight: 506.555
• European Community (EC) Number: 248-926-6
• DSSTox Substance ID: DTXSID20950972
• Nikkaji Number: J250.685H
• Wikidata: Q82929188
• Mol file: 28252-49-5.mol

Synonyms:28252-49-5;Z-Gln(Dod)-OH;N-(Bis(4-methoxyphenyl)methyl)-N2-((phenylmethoxy)carbonyl)-L-glutamine;EINECS 248-926-6;(2S)-5-[bis(4-methoxyphenyl)methylamino]-5-oxo-2-(phenylmethoxycarbonylamino)pentanoic acid;N-[bis(4-methoxyphenyl)methyl]-N2-[(phenylmethoxy)carbonyl]-L-glutamine;C28-H30-N2-O7;DTXSID20950972;Nalpha-Z-Ndelta-4,4'-dimethoxydityl-L-glutamine;(S)-2-(benzyloxycarbonylamino)-5-(bis(4-methoxyphenyl)methylamino)-5-oxopentanoic acid;(S)-2-(((Benzyloxy)carbonyl)amino)-5-((bis(4-methoxyphenyl)methyl)amino)-5-oxopentanoic acid;(S)-2-(((Benzyloxy)carbonyl)amino)-5-((bis(4-methoxyphenyl)methyl)amino)-5-oxopentanoicacid;N-[(Benzyloxy)(hydroxy)methylidene]-5-{[bis(4-methoxyphenyl)methyl]imino}-5-hydroxynorvaline

Chemical Property of N-(Bis(4-methoxyphenyl)methyl)-N2-((phenylmethoxy)carbonyl)-L-glutamine

Chemical Property:

• Vapor Pressure: 2.88E-26mmHg at 25°C
• Boiling Point: 789.5°Cat760mmHg
• PKA: 3.82±0.10(Predicted)
• Flash Point: 431.3°C
• PSA: 123.19000
• Density: 1.244g/cm³
• LogP: 4.85100
• Storage Temp.: -15°C
• XLogP3: 3.8
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 13
• Exact Mass: 506.20530130
• Heavy Atom Count: 37
• Complexity: 687

Purity/Quality:

98%Min ^*data from raw suppliers

(S)-2-(((Benzyloxy)carbonyl)amino)-5-((bis(4-methoxyphenyl)methyl)amino)-5-oxopentanoicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C(C2=CC=C(C=C2)OC)NC(=O)CCC(C(=O)O)NC(=O)OCC3=CC=CC=C3
• Isomeric SMILES: COC1=CC=C(C=C1)C(C2=CC=C(C=C2)OC)NC(=O)CC[C@@H](C(=O)O)NC(=O)OCC3=CC=CC=C3

Technology Process of N-(Bis(4-methoxyphenyl)methyl)-N2-((phenylmethoxy)carbonyl)-L-glutamine

There total 4 articles about N-(Bis(4-methoxyphenyl)methyl)-N2-((phenylmethoxy)carbonyl)-L-glutamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Cbz-L-Gln (2650-64-8) + 4,4'-Dimethoxybenzhydrol (728-87-0) → Z-Gln(Mbh) (28252-49-5)

Guidance literature:

DOI:10.1007/BF00910279

Reference yield:

bis(p-methoxyphenyl)methanone (90-96-0) → Z-Gln(Mbh) (28252-49-5)

Guidance literature:

Multi-step reaction with 2 steps

1: NaBH₄ / ethanol

2: H₂SO₄ / acetic acid

With sodium tetrahydroborate; sulfuric acid; In ethanol; acetic acid;

DOI:10.1002/cber.19701030706

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → Z-Gln(Mbh) (28252-49-5)

Guidance literature:

DOI:10.1007/BF00910279

upstream raw materials:

Cbz-L-Gln

4,4'-Dimethoxybenzhydrol

bis(p-methoxyphenyl)methanone

benzyl chloroformate

Downstream raw materials:

Nps-Gln(Mbh)

H-Gln(DOD)-OMe

Z-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Hcy(Bzl)-NH₂

Z-Pro-Gln(Mbh)-Gln(Mbh)-Phe-O-t-Bu