2-Pyridinecarboxylicacid,4-cyano-(9CI)

Base Information

• Chemical Name: 2-Pyridinecarboxylicacid,4-cyano-(9CI)
• CAS No.: 640296-19-1
• Molecular Formula: C7H4N2O2
• Molecular Weight: 148.121
• Hs Code.: 2933399090
• Mol file: 640296-19-1.mol

Synonyms:4-cyano-pyridine-2-carboxylic acid;4-CYANOPICOLINIC ACID;4-cyano-2-pyridinecarboxylic acid;4-Cyano-picolinsaeure;

Chemical Property of 2-Pyridinecarboxylicacid,4-cyano-(9CI)

Chemical Property:

• Melting Point: ca 210℃
• PSA: 73.98000
• LogP: 0.65148
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4-Cyanopyridine-2-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-cyanopyridine, and p- chlorobenzonitrile system which produces only amides, without the corresponding carboxylic acids.

Technology Process of 2-Pyridinecarboxylicacid,4-cyano-(9CI)

There total 1 articles about 2-Pyridinecarboxylicacid,4-cyano-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 4-cyanopyridine-2-carboxylic acid (640296-19-1)

Guidance literature:

4-Cyano-picolinsaeure-methylester (X), 10percentig. wss. HCl (Δ);

Reference yield: 42.0%

4-amino-1-[4-(hydroxymethyl)phenyl]pyrazole-3-carboxamide + 4-cyanopyridine-2-carboxylic acid (640296-19-1) → N-[3-carbamoyl-1-[4-(hydroxymethyl)phenyl]pyrazol-4-yl]-4-cyanopyridine-2-carboxamide

Guidance literature:

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 25 ℃; for 1h;

Reference yield:

(-)-(S)-2-(4-amino-3-fluorophenyl)-morpholine-4-carboxylic acid tert-butyl ester (1400997-48-9) + 4-cyanopyridine-2-carboxylic acid (640296-19-1) → (S)-2-{4-[(4-Cyano-pyridine-2-carbonyl)-amino]-3-fluoro-phenyl}-morpholine-4-carboxylic acid tert-butyl ester (1415757-59-3)

Guidance literature:

With 4-methyl-morpholine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 17h;

Downstream raw materials:

4-{2-[(4-cyano-pyridine-2-carbonyl)-amino]-phenoxy}-phthalic acid dimethyl ester

(S)-2-{4-[(4-Cyano-pyridine-2-carbonyl)-amino]-3-fluoro-phenyl}-morpholine-4-carboxylic acid tert-butyl ester

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