2-(2-Morpholin-4-ylethoxy)aniline

Base Information

• Chemical Name: 2-(2-Morpholin-4-ylethoxy)aniline
• CAS No.: 64039-56-1
• Molecular Formula: C12H18N2O2
• Molecular Weight: 222.287
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID40424483
• Mol file: 64039-56-1.mol

Synonyms:64039-56-1;2-(2-Morpholinoethoxy)aniline;2-(2-morpholin-4-ylethoxy)aniline;2-(2-Morpholin-4-yl-ethoxy)-phenylamine;2-[2-(morpholin-4-yl)ethoxy]aniline;2-(2-MORPHOLINOETHOXY)ANILINE, HCL;SCHEMBL1853220;DTXSID40424483;HMS1704K09;AMY27247;BBL036334;MFCD04970982;STK346738;AKOS000113493;CS-0269692;FT-0640919;EN300-229871;A867957;J-505673

Chemical Property of 2-(2-Morpholin-4-ylethoxy)aniline

Chemical Property:

• Vapor Pressure: 5.8E-06mmHg at 25°C
• Melting Point: 41oC
• Boiling Point: 379.6oC at 760 mmHg
• PKA: 6.41±0.10(Predicted)
• Flash Point: 183.4oC
• PSA: 47.72000
• Density: 1.129g/cm3
• LogP: 1.49890
• Storage Temp.: 2-8°C
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 222.136827821
• Heavy Atom Count: 16
• Complexity: 196

Purity/Quality:

98%min ^*data from raw suppliers

2-(2-Morpholin-4-yl-ethoxy)-phenylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C,Xi
• Hazard Codes: C,Xi
• Statements: 20/21/22-34
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCN1CCOC2=CC=CC=C2N

Technology Process of 2-(2-Morpholin-4-ylethoxy)aniline

There total 7 articles about 2-(2-Morpholin-4-ylethoxy)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

4-(2-(2-nitrophenoxy)ethyl)morpholine (105337-21-1) → 2-[2-(morpholin-4-yl)ethoxy]aniline (64039-56-1)

Guidance literature:

With tin(II) chloride dihdyrate; In ethanol; at 80 ℃; for 2h;

DOI:10.3390/molecules21050677

Reference yield:

2-(morpholin-4-yl)ethanol (622-40-2) → 2-[2-(morpholin-4-yl)ethoxy]aniline (64039-56-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / N,N-dimethyl-formamide / 12 h / -35 °C

2: tin(II) chloride dihdyrate / ethanol / 2 h / 80 °C

With tin(II) chloride dihdyrate; sodium hydride; In ethanol; N,N-dimethyl-formamide;

DOI:10.3390/molecules21050677

Reference yield:

ortho-nitrofluorobenzene (1493-27-2,127723-77-7) → 2-[2-(morpholin-4-yl)ethoxy]aniline (64039-56-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / N,N-dimethyl-formamide / 12 h / -35 °C

2: tin(II) chloride dihdyrate / ethanol / 2 h / 80 °C

With tin(II) chloride dihdyrate; sodium hydride; In ethanol; N,N-dimethyl-formamide;

DOI:10.3390/molecules21050677

upstream raw materials:

4-(2-(2-nitrophenoxy)ethyl)morpholine

N-(2-chlorethyl)morpholine

2-hydroxynitrobenzene

4-(2-chloroethyl)morpholine hydrochride

Downstream raw materials:

1-phenyl-4-[N-[2-(2'-morpholinoethoxy)phenyl]aminomethyl]-1H-1,2,3-triazole

1-(2'-chlorophenyl)-4-[N-[2-(2'-morpholinoethoxy)phenyl]aminomethyl]-1H-1,2,3-triazole

1-(4'-methoxyphenyl)-4-[N-[2-(2'-morpholinoethoxy)phenyl]aminomethyl]-1H-1,2,3-triazole

1-(2'-nitrophenyl)-4-[N-[2-(2'-morpholinoethoxy)phenyl]aminomethyl]-1H-1,2,3-triazole

Refernces

• 1、 Mao, Ming-Zhen,Li, Yu-Xin,Zhou, Yun-Yun,Chen, Wei,Liu, Tuan-Wei,Yu, Shu-Jing,Wang, Su-Hua,Li, Zheng-Ming. "Synthesis and Biological Activity of Novel 1-Substituted Phenyl-4-[N-[(2'-morpholinothoxy)phenyl]aminomethyl]-1H-1,2,3-Triazoles". scheme or table. p. 695 - 699. Retrieved 2012/04/17.