Tazettadiol

Base Information

• Chemical Name: Tazettadiol
• CAS No.: 466-66-0
• Molecular Formula: C18H23NO5
• Molecular Weight: 333.37900
• Mol file: 466-66-0.mol

Synonyms:(3S,3aS,6S,7aS)-3a-(6-Hydroxymethyl-benzo[1,3]dioxol-5-yl)-6-methoxy-1-methyl-2,3,3a,6,7,7a-hexahydro-1H-indol-3-ol;Tazettadiol;(+)-tazettadiol;(3aS)-3a-(6-hydroxymethyl-benzo[1,3]dioxol-5-yl)-6c-methoxy-1-methyl-(3ar,7ac)-2,3,3a,6,7,7a-hexahydro-indol-3c-ol;

Chemical Property of Tazettadiol

Chemical Property:

• PSA: 71.39000
• LogP: 0.73310

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Tazettadiol

There total 5 articles about Tazettadiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.5%

tazettine (507-79-9,545-16-4,1361-35-9,28405-99-4,60944-17-4) → tazettadiol (466-66-0) + 3α-hydroxy-3aβ-(2-hydroxymethyl-4,5-methylenedioxyphenyl)-6β-methoxy-N-methyl-2,3,6,7-tetrahydro-7aH-indole (73060-68-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 10h; Ambient temperature;

DOI:10.1248/cpb.28.2924

Reference yield:

3α-hydroxy-3aβ-(2-hydroxymethyl-4,5-methylenedioxyphenyl)-6β-methoxy-N-methyl-2,3,6,7-tetrahydro-7aH-indole (73060-68-1) → tazettadiol (466-66-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 9.4 percent / MnO₂ / CHCl₃ / 1.33 h / Ambient temperature

2: 62.7 percent / LAH / tetrahydrofuran / 10 h / Ambient temperature

With manganese(IV) oxide; lithium aluminium tetrahydride; In tetrahydrofuran; chloroform;

DOI:10.1248/cpb.28.2924

Reference yield:

tazettine (507-79-9,545-16-4,1361-35-9,28405-99-4,60944-17-4) → tazettadiol (466-66-0)

Guidance literature:

With tetrahydrofuran; lithium aluminium tetrahydride;

upstream raw materials:

tazettine

tetrahydrofuran

3α-hydroxy-3aβ-(2-hydroxymethyl-4,5-methylenedioxyphenyl)-6β-methoxy-N-methyl-2,3,6,7-tetrahydro-7aH-indole

Refernces