Technology Process of 5,4'-Dihydroxy-3,6,7,8,3'-pentamethoxyflavone
There total 12 articles about 5,4'-Dihydroxy-3,6,7,8,3'-pentamethoxyflavone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
methanol; ethyl acetate;
DOI:10.1248/cpb.43.2054
- Guidance literature:
-
Multi-step reaction with 9 steps
1: pyridine / 2 h / 60 - 80 °C
2: KOH, pyridine / 2 h / 60 - 70 °C
3: H2SO4, AcOH / 1 h / 50 °C
4: 100 percent / N,N-diisopropylethylamine / CH2Cl2
5: 1.) dimethyldioxirane, 2.) TsOH / 1.) acetone, CH2Cl2, 0 deg C, 12 h, 2.) CH2Cl2, 0 deg C, 20 min
6: conc. HCl / acetic acid / 2 h / Ambient temperature
7: K2CO3 / acetone / Heating
8: AlBr3 / acetonitrile / 0.67 h / 0 °C
9: H2 / 10percent Pd/C / methanol; ethyl acetate
With
pyridine; hydrogenchloride; potassium hydroxide; aluminum tri-bromide; sulfuric acid; hydrogen; 3,3-dimethyldioxirane; potassium carbonate; toluene-4-sulfonic acid; acetic acid; N-ethyl-N,N-diisopropylamine;
palladium on activated charcoal;
In
methanol; dichloromethane; acetic acid; ethyl acetate; acetone; acetonitrile;
DOI:10.1248/cpb.43.2054
- Guidance literature:
-
Multi-step reaction with 10 steps
1: N,N-diisopropylethylamine / CH2Cl2 / 4 h / Ambient temperature
2: pyridine / 2 h / 60 - 80 °C
3: KOH, pyridine / 2 h / 60 - 70 °C
4: H2SO4, AcOH / 1 h / 50 °C
5: 100 percent / N,N-diisopropylethylamine / CH2Cl2
6: 1.) dimethyldioxirane, 2.) TsOH / 1.) acetone, CH2Cl2, 0 deg C, 12 h, 2.) CH2Cl2, 0 deg C, 20 min
7: conc. HCl / acetic acid / 2 h / Ambient temperature
8: K2CO3 / acetone / Heating
9: AlBr3 / acetonitrile / 0.67 h / 0 °C
10: H2 / 10percent Pd/C / methanol; ethyl acetate
With
pyridine; hydrogenchloride; potassium hydroxide; aluminum tri-bromide; sulfuric acid; hydrogen; 3,3-dimethyldioxirane; potassium carbonate; toluene-4-sulfonic acid; acetic acid; N-ethyl-N,N-diisopropylamine;
palladium on activated charcoal;
In
methanol; dichloromethane; acetic acid; ethyl acetate; acetone; acetonitrile;
DOI:10.1248/cpb.43.2054