N-BOC-3-BROMO-5-TRIFLUOROMETHYLANILINE

Base Information

• Chemical Name: N-BOC-3-BROMO-5-TRIFLUOROMETHYLANILINE
• CAS No.: 641571-03-1
• Molecular Formula: C12H13BrF3NO2
• Molecular Weight: 340.14
• Mol file: 641571-03-1.mol

Synonyms:tert-butyl N-[3-bromo-5-(trifluoromethyl)phenyl]carbamate;

Chemical Property of N-BOC-3-BROMO-5-TRIFLUOROMETHYLANILINE

Chemical Property:

• PSA: 38.33000
• LogP: 4.88790
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl (3-bromo-5-(trifluoromethyl)-phenyl)carbamate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-BOC-3-BROMO-5-TRIFLUOROMETHYLANILINE

There total 1 articles about N-BOC-3-BROMO-5-TRIFLUOROMETHYLANILINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + [3-bromo-5-(trifluoromethyl)phenyl]amine (54962-75-3) → (3-Bromo-5-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (641571-03-1)

Guidance literature:

With dmap; In acetonitrile; at 60 ℃; for 8h;

Reference yield: 70.0%

5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine (754214-56-7) + (3-Bromo-5-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (641571-03-1) → tert-butyl (3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-5-(trifluoromethyl)phenyl)carbamate

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; In 1,4-dioxane; water; at 120 ℃; for 1h; Microwave irradiation;

Reference yield: 47.0%

(3-Bromo-5-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (641571-03-1) + Triisopropyl borate (5419-55-6) → 5-trifluoromethyl-3-(tert-butyl-oxycarbonyl)amino-phenylboronic acid (1207351-03-8)

Guidance literature:

(3-Bromo-5-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester; Triisopropyl borate; With n-butyllithium; In tetrahydrofuran; hexane; toluene; at -70 ℃; for 1.33333h; Inert atmosphere;

With hydrogenchloride; water; In tetrahydrofuran; hexane; toluene; at -20 - 20 ℃;

upstream raw materials:

di-tert-butyl dicarbonate

[3-bromo-5-(trifluoromethyl)phenyl]amine

Downstream raw materials:

5-trifluoromethyl-3-(tert-butyl-oxycarbonyl)amino-phenylboronic acid