6-Quinolinol, 8-methyl-

Base Information

• Chemical Name: 6-Quinolinol, 8-methyl-
• CAS No.: 64165-33-9
• Molecular Formula: C10H9NO
• Molecular Weight: 159.18500
• Mol file: 64165-33-9.mol

Synonyms:8-Methyl-quinolin-6-ol;8-Methyl-chinolin-6-ol;6-Quinolinol, 8-methyl-;

Chemical Property of 6-Quinolinol, 8-methyl-

Chemical Property:

• PSA: 33.12000
• LogP: 2.24880

Purity/Quality:

NLT 98% ^*data from raw suppliers

8-Methylquinolin-6-ol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Quinolinol, 8-methyl-

There total 5 articles about 6-Quinolinol, 8-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 1.0%

6-hydroxy-8-methyl-1,2,3,4-tetrahydroquinoline → 6-hydroxy-8-methylquinoline (64165-33-9)

Guidance literature:

With glucose dehydrogenase; D-glucose; cytochrome P₄₅₀ enzyme CYP₁₀₂A₁ R₄₇L/Y₅₁F/H₁₇₁L/I₂₆₃G/Q₃₀₇H/N₃₁₉Y/A₃₂₈L mutant; C₂₁H₂₅N₇O₁₇P₃^(3-)*2H⁽¹⁺⁾*Na⁽¹⁺⁾; In aq. phosphate buffer; ethanol; at 20 ℃; for 16h; pH=8.4; Catalytic behavior; Enzymatic reaction;

DOI:10.1002/anie.201904157

Reference yield:

6-methoxy-8-methylquinoline → 6-hydroxy-8-methylquinoline (64165-33-9)

Guidance literature:

With boron tribromide; In dichloromethane; at 0 - 20 ℃; for 6h;

DOI:10.1039/d1cc04418d

Reference yield:

2-methyl-4-methoxyaniline (102-50-1) → 6-hydroxy-8-methylquinoline (64165-33-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid; sodium iodide / 6 h / 140 °C

2: boron tribromide / dichloromethane / 6 h / 0 - 20 °C

With sulfuric acid; boron tribromide; sodium iodide; In dichloromethane;

DOI:10.1039/d1cc04418d

upstream raw materials:

8-methyl-1,2,3,4-tetrahydroquinoline

2-methyl-4-methoxyaniline

Refernces

• 1、 Li, Yushu,Wong, Luet L.. "Multi-Functional Oxidase Activity of CYP102A1 (P450BM3) in the Oxidation of Quinolines and Tetrahydroquinolines". supporting information. p. 9551 - 9555. Retrieved 2019/08/06.