N-Benzyl-N-(methanesulfonyl)methanesulfonamide

Base Information

• Chemical Name: N-Benzyl-N-(methanesulfonyl)methanesulfonamide
• CAS No.: 64183-75-1
• Molecular Formula: C9H13NO4S2
• Molecular Weight: 263.339
• DSSTox Substance ID: DTXSID20495752
• Nikkaji Number: J923.105F
• Wikidata: Q82344060
• Mol file: 64183-75-1.mol

Synonyms:64183-75-1;N-Benzyl-N-(methanesulfonyl)methanesulfonamide;SCHEMBL2492170;DTXSID20495752

Chemical Property of N-Benzyl-N-(methanesulfonyl)methanesulfonamide

Chemical Property:

• XLogP3: 0.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 263.02860024
• Heavy Atom Count: 16
• Complexity: 377

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CS(=O)(=O)N(CC1=CC=CC=C1)S(=O)(=O)C

Technology Process of N-Benzyl-N-(methanesulfonyl)methanesulfonamide

There total 4 articles about N-Benzyl-N-(methanesulfonyl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

trimethylsilyldimesylamine (30488-04-1) + benzyl chloroformate (501-53-1,94274-21-2) → N-(benzyl)dimethyldisulfonimide (64183-75-1)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1080/10426509608046422

Reference yield: 71.0%

N-benzylmethanesulfonamide (3989-45-5) + benzylamine (100-46-9) → N-(benzyl)dimethyldisulfonimide (64183-75-1)

Guidance literature:

N-benzylmethanesulfonamide; With sodium hydride; In tetrahydrofuran; for 0.5h;

benzylamine; In tetrahydrofuran; for 1h; Further stages.;

DOI:10.1021/ja002465v

Reference yield:

benzylamine (100-46-9) → N-(benzyl)dimethyldisulfonimide (64183-75-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 73 percent / tetrahydrofuran / 3 h / 0 °C

2.1: NaH / tetrahydrofuran / 0.5 h

2.2: 71 percent / tetrahydrofuran / 1 h

With sodium hydride; In tetrahydrofuran;

DOI:10.1021/ja002465v

upstream raw materials:

trimethylsilyldimesylamine

benzyl chloroformate

N-benzylmethanesulfonamide

benzylamine