2H-Isoindole-2-acetamide, N-[[4-[4-chloro-2-(2-chlorobenzoyl)phenyl]-5-methyl-4H-1,2,4-triazol-3-yl ]methyl]-1,3-dihydro-1,3-dioxo-a-(phenylmethyl)-, (S)-

Base Information

Chemical Name:2H-Isoindole-2-acetamide, N-[[4-[4-chloro-2-(2-chlorobenzoyl)phenyl]-5-methyl-4H-1,2,4-triazol-3-yl ]methyl]-1,3-dihydro-1,3-dioxo-a-(phenylmethyl)-, (S)-
CAS No.:64195-39-7
Molecular Formula:C34H25Cl2N5O4
Molecular Weight:638.51
Hs Code.:

2H-Isoindole-2-acetamide,
N-[[4-[4-chloro-2-(2-chlorobenzoyl)phenyl]-5-methyl-4H-1,2,4-triazol-3-yl
]methyl]-1,3-dihydro-1,3-dioxo-a-(phenylmethyl)-, (S)-

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2H-Isoindole-2-acetamide, N-[[4-[4-chloro-2-(2-chlorobenzoyl)phenyl]-5-methyl-4H-1,2,4-triazol-3-yl ]methyl]-1,3-dihydro-1,3-dioxo-a-(phenylmethyl)-, (S)-

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Technology Process of 2H-Isoindole-2-acetamide, N-[[4-[4-chloro-2-(2-chlorobenzoyl)phenyl]-5-methyl-4H-1,2,4-triazol-3-yl ]methyl]-1,3-dihydro-1,3-dioxo-a-(phenylmethyl)-, (S)-

There total 12 articles about 2H-Isoindole-2-acetamide, N-[[4-[4-chloro-2-(2-chlorobenzoyl)phenyl]-5-methyl-4H-1,2,4-triazol-3-yl ]methyl]-1,3-dihydro-1,3-dioxo-a-(phenylmethyl)-, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.3%

: 64194-71-4
2',5-dichloro-2-<3-(aminomethyl)-5-methyl-4H-1,2,4-triazol-4-yl>benzophenone dihydrobromide

: 32150-91-7
phthaloyl-L-phenylalanyl chloride

: 64195-39-7
2',5-dichloro-2-<3-<<(phthaloyl-L-phenylalanyl)amino>methyl>-5-methyl-4H-1,2,4-triazol-4-yl>benzophenone

Guidance literature:: In N,N-dimethyl-formamide; benzene; at 0 - 20 ℃;
DOI:10.1021/jm00354a015

Reference yield:

: 64194-71-4
2',5-dichloro-2-<3-(aminomethyl)-5-methyl-4H-1,2,4-triazol-4-yl>benzophenone dihydrobromide

: 56271-33-1
3-phenyl-2-(phthalimido)propanoyl chloride

: 64195-39-7
N-{4-[4-chloro-2-(2-chloro-benzoyl)-phenyl]-5-methyl-4H-[1,2,4]triazol-3-ylmethyl}-3-phenyl-2-phthalimido-propionamide

Guidance literature:: With sodium hydrogencarbonate; In N-methyl-acetamide; benzene;

Reference yield:

: 2958-36-3,53960-29-5
(2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone

: 64195-39-7
2',5-dichloro-2-<3-<<(phthaloyl-L-phenylalanyl)amino>methyl>-5-methyl-4H-1,2,4-triazol-4-yl>benzophenone

Guidance literature:: Multi-step reaction with 5 steps

2: 17 percent / AcOH / ethanol / 6 h / Ambient temperature

4: 99 percent / 30percent HBr, AcOH / acetonitrile / 1.) RT, 1.5 h, 2.) reflux, 1 h

5: 68.3 percent / benzene; dimethylformamide / 0 - 20 °C

With hydrogen bromide; acetic acid; In ethanol; N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1021/jm00354a015