benzhydryl (6R,7E)-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-7-(p-tolylsulfanylimino)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

Base Information

• Chemical Name: benzhydryl (6R,7E)-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-7-(p-tolylsulfanylimino)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
• CAS No.: 64278-67-7
• Molecular Formula: C30H26N6O3S3
• Molecular Weight: 614.773

Synonyms:7-[(4-Methylphenylthio)-imino]-3-[(1-methyl-1H-tetrazol-5-ylthio)-methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-carbonsaeurediphenylmethylester;

Chemical Property of benzhydryl (6R,7E)-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-7-(p-tolylsulfanylimino)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

Chemical Property:

• PSA: 178.47000
• LogP: 5.19880

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of benzhydryl (6R,7E)-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-7-(p-tolylsulfanylimino)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

There total 8 articles about benzhydryl (6R,7E)-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-7-(p-tolylsulfanylimino)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

p-methylbenzenesulfenyl chloride (933-00-6) + 7β-amino-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>ceph-3-em-4-oic acid benzhydryl ester (53090-86-1) → (6R)-7-<<(4-methylphenyl)thio>imino>-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-8-oxo-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylic acid diphenylmethyl ester (64278-67-7)

Guidance literature:

With methyloxirane; In dichloromethane; for 3h; molecular sieves; 0-5 deg C to 25 deg C;

DOI:10.1021/ja00525a038

Reference yield: 64.7%

p-methylbenzenesulfenyl chloride (933-00-6) + 7β-amino-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>ceph-3-em-4-oic acid benzhydryl ester (53090-86-1) → (6R)-7-<<(4-methylphenyl)thio>imino>-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-8-oxo-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylic acid diphenylmethyl ester (64278-67-7) + (6R,7R)-3-(1-Methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-7-p-tolylsulfanylamino-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester (64278-66-6) + C37H34N6O3S4 (64278-68-8)

Guidance literature:

With methyloxirane; In dichloromethane; at 0 ℃; for 2h;

DOI:10.1021/ja00525a038

Reference yield:

p-methylbenzenesulfenyl chloride (933-00-6) + (6R,7R)-3-(1-Methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-7-p-tolylsulfanylamino-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester (64278-66-6) → di(p-tolyl) disulfide (103-19-5) + (6R)-7-<<(4-methylphenyl)thio>imino>-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-8-oxo-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylic acid diphenylmethyl ester (64278-67-7)

Guidance literature:

With methyloxirane; In dichloromethane; molecular sieves;

DOI:10.1021/ja00525a038

upstream raw materials:

p-methylbenzenesulfenyl chloride

(6R,7R)-3-(1-Methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-7-p-tolylsulfanylamino-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

7β-amino-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>ceph-3-em-4-oic acid benzhydryl ester

4-methylbenzenesulfinyl chloride

Downstream raw materials:

7β-amino-7α-[(4-methylphenyl)thio]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo-[4.2.0]oct-2-ene-2-carboxylic acid, diphenylmethyl ester

(6R,7S)-7-Methoxy-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2-carboxylic acid benzhydryl ester

(6R-cis)-7-methoxy-3-<<(1-methyl-1-H-tetrazol-5-yl)thio>methyl>-8-oxo<(phenylacetyl)amino>-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylic acid diphenylmethyl ester

(6R-cis)-7-amino-7-<(4-methylphenyl)thio>-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-8-oxo-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylic acid diphenylmethyl ester

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