5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(acetyloxy)methyl]-7-[[(4-methylphenyl)thio]imino]-8-oxo-, diphenylmethyl ester, (R)-

Base Information

Chemical Name:5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(acetyloxy)methyl]-7-[[(4-methylphenyl)thio]imino]-8-oxo-, diphenylmethyl ester, (R)-
CAS No.:64278-69-9
Molecular Formula:C30H26N2O5S2
Molecular Weight:558.679
Hs Code.:

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,
3-[(acetyloxy)methyl]-7-[[(4-methylphenyl)thio]imino]-8-oxo-,
diphenylmethyl ester, (R)-

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(acetyloxy)methyl]-7-[[(4-methylphenyl)thio]imino]-8-oxo-, diphenylmethyl ester, (R)-

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Technology Process of 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(acetyloxy)methyl]-7-[[(4-methylphenyl)thio]imino]-8-oxo-, diphenylmethyl ester, (R)-

There total 1 articles about 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(acetyloxy)methyl]-7-[[(4-methylphenyl)thio]imino]-8-oxo-, diphenylmethyl ester, (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 933-00-6
p-methylbenzenesulfenyl chloride

: 27266-61-1,54600-89-4
benzhydryl 7-aminocephalosporanate

: 64278-69-9
C₃₀H₂₆N₂O₅S₂

Guidance literature:: With potassium carbonate; In dichloromethane; at 0 - 5 ℃; for 1h;
DOI:10.1021/ja00525a038

Reference yield:

: 64278-69-9
(R)-3-acetoxymethyl-8-oxo-7-p-tolylsulfanylimino-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

: 71955-66-3
(6R)-3-acetoxymethyl-8-oxo-7t-(2-oxo-ethyl)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Guidance literature:: Multi-step reaction with 4 steps

1: Ph₃P

2: HgCl₂ / H₂O; 1,2-dimethoxy-ethane

3: aq. HCl / benzene

4: H₂ / Pd-C / ethyl acetate

With hydrogenchloride; hydrogen; triphenylphosphine; mercury dichloride; palladium on activated charcoal; In 1,2-dimethoxyethane; water; ethyl acetate; benzene;
DOI:10.1016/S0040-4039(01)93611-1

Reference yield:

: 64278-69-9
(R)-3-acetoxymethyl-8-oxo-7-p-tolylsulfanylimino-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

: 71955-67-4
(6R)-3-acetoxymethyl-8-oxo-7c-(2-oxo-ethyl)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Guidance literature:: Multi-step reaction with 4 steps

1: Ph₃P

2: HgCl₂ / H₂O; 1,2-dimethoxy-ethane

3: aq. HCl / benzene

4: H₂ / Pd-C / ethyl acetate

With hydrogenchloride; hydrogen; triphenylphosphine; mercury dichloride; palladium on activated charcoal; In 1,2-dimethoxyethane; water; ethyl acetate; benzene;
DOI:10.1016/S0040-4039(01)93611-1