Carbamic acid, [(1S,3S)-3-aminocyclopentyl]-, 1,1-dimethylethyl ester (9CI)

Base Information

• Chemical Name: Carbamic acid, [(1S,3S)-3-aminocyclopentyl]-, 1,1-dimethylethyl ester (9CI)
• CAS No.: 645400-44-8
• Molecular Formula: C10H20N2O2
• Molecular Weight: 200.281
• Hs Code.: 2924297099
• Mol file: 645400-44-8.mol

Synonyms:tert-butyl N-[(1S,3S)-3-aminocyclopentyl]carbamate;

Chemical Property of Carbamic acid, [(1S,3S)-3-aminocyclopentyl]-, 1,1-dimethylethyl ester (9CI)

Chemical Property:

• Boiling Point: 304.2±31.0 °C(Predicted)
• PKA: 12.37±0.40(Predicted)
• PSA: 64.35000
• Density: 1.04±0.1 g/cm3(Predicted)
• LogP: 2.48210
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl((1S,3S)-3-Aminocyclopentyl)carbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: tert-butyl N-[(1S,3S)-3-aminocyclopentyl]carbamate is used as a reactant in the synthesis of C-2 hydroxyethyl imidazopyrrolo pyridines as JAK1 inhibitors.

Technology Process of Carbamic acid, [(1S,3S)-3-aminocyclopentyl]-, 1,1-dimethylethyl ester (9CI)

There total 3 articles about Carbamic acid, [(1S,3S)-3-aminocyclopentyl]-, 1,1-dimethylethyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl tert-butyl (1S,3S)-cyclopentane-1,3-diylbiscarbamate (847417-31-6,1315495-87-4,881891-89-0) → tert-butyl [(1S,3S)-3-aminocyclopentyl]carbamate (645400-44-8,1197398-99-4,454709-98-9,947732-58-3)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethanol; for 1h; under 1861.78 Torr;

Reference yield:

tert-butyl [(1S,3S)-3-azidocyclopentyl]carbamate (645400-43-7) → tert-butyl [(1S,3S)-3-aminocyclopentyl]carbamate (645400-44-8,1197398-99-4,454709-98-9,947732-58-3)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol;

Reference yield:

(1S,3S)-3-[(tert-butoxycarbonyl)amino]cyclopentanecarboxylic acid → tert-butyl [(1S,3S)-3-aminocyclopentyl]carbamate (645400-44-8,1197398-99-4,454709-98-9,947732-58-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: diphenyl phosphoryl azide; triethylamine / toluene / 3 h / 90 °C

1.2: 16 h

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 1 h / 1861.78 Torr

With diphenyl phosphoryl azide; hydrogen; triethylamine; palladium 10% on activated carbon; In ethanol; toluene;

upstream raw materials:

benzyl tert-butyl (1S,3S)-cyclopentane-1,3-diylbiscarbamate

tert-butyl [(1S,3S)-3-azidocyclopentyl]carbamate

Downstream raw materials:

tert-butyl (1S,3S)-3-{[difluoro(4-methylphenyl)acetyl]amino}cyclopentylcarbamate

C₂₃H₂₇N₅O₆S

C₂₃H₂₄F₃N₅O₃S

C₂₁H₂₃N₅O₃S

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 645400-44-8 Carbamic acid, [(1S,3S)-3-aminocyclopentyl]-, 1,1-dimethylethyl ester (9CI)

Send

Send

Metric Ton KG G Pound L ML

Send

Send