Technology Process of 3-Furanpropanoic acid, a-aminotetrahydro-, methyl ester
There total 2 articles about 3-Furanpropanoic acid, a-aminotetrahydro-, methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(tetrahydrofuran-3-yl)methyl methanesulfonate; methyl N-(diphenylmethylene)glycinate;
In
N,N-dimethyl-formamide; toluene;
at 20 ℃;
With
hydrogenchloride;
In
N,N-dimethyl-formamide; toluene;
for 0.5h;
DOI:10.1021/jo061977a
- Guidance literature:
-
3-(bromomethyl)oxolane; methyl N-(diphenylmethylene)glycinate;
With
potassium tert-butylate;
In
DMF (N,N-dimethyl-formamide); toluene;
at 20 ℃;
for 16.75h;
With
hydrogenchloride;
In
DMF (N,N-dimethyl-formamide); water; toluene;
for 0.5h;
With
potassium carbonate;
In
water;
pH=8 - 9;
- Guidance literature:
-
methyl 2-amino-3-(tetrahydrofuran-3-yl)-propionate;
With
hydrogen bromide;
In
water;
at 110 - 120 ℃;
for 8h;
Heating in a sealed tube;
With
ammonia;
In
water;
for 4h;
Heating / reflux;
With
sulfuric acid; sodium hydrogencarbonate;
more than 3 stages;