Butanoic acid, 3-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-4-[(triphenylmethyl)thio]-, (3R)-

Base Information

Chemical Name:Butanoic acid, 3-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-4-[(triphenylmethyl)thio]-, (3R)-
CAS No.:646068-80-6
Molecular Formula:C₃₈H₃₃NO₄S
Molecular Weight:599.75
Hs Code.:

Synonyms:(R)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-[(triphenylmethyl)sulfanyl]butanoic acid;Fmoc-β3hCys(Trt)-OH;(R)-3-(9H-Fluoren-9-ylmethoxycarbonylamino)-4-tritylsulfanyl-butyric acid;Fmoc-(R)-β3hCys(Tr)-OH;

Suppliers and Price of Butanoic acid, 3-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-4-[(triphenylmethyl)thio]-, (3R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 9 raw suppliers

Chemical Property of Butanoic acid, 3-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-4-[(triphenylmethyl)thio]-, (3R)-

Chemical Property:

Melting Point:88-90 °C
Boiling Point:780.1±60.0 °C(Predicted)
PSA：100.93000
Density:1.256±0.06 g/cm3(Predicted)
LogP:8.48460

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Butanoic acid, 3-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-4-[(triphenylmethyl)thio]-, (3R)-

There total 8 articles about Butanoic acid, 3-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-4-[(triphenylmethyl)thio]-, (3R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 76-83-5
trityl chloride

: 712351-75-2
Fmoc-(R)-β³hCys-OH

: 646068-80-6
(R)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-[(triphenylmethyl)sulfanyl]butanoic acid

Guidance literature:: With 4-methyl-morpholine; In chloroform;
DOI:10.1002/hlca.200390215

Reference yield:

: 86060-81-3
S-[(acetylamino)methyl]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-cysteine

: 646068-80-6
(R)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-[(triphenylmethyl)sulfanyl]butanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-methylmorpholine; ClCO₂Et / tetrahydrofuran / 0.5 h / -25 °C

1.2: 7.4 g / diethyl ether; tetrahydrofuran / 4 h / 0 - 20 °C

2.1: 3.2 g / acetonitrile; H₂O / 0 °C / Irradiation

3.1: Hg(OAc)2 / tetrahydrofuran; H₂O; acetic acid / 20 °C

4.1: 4.4 g / N-methylmorpholine / CHCl₃ / 15 h / 0 - 20 °C

With 4-methyl-morpholine; mercury(II) diacetate; chloroformic acid ethyl ester; In tetrahydrofuran; chloroform; water; acetic acid; acetonitrile;
DOI:10.1002/hlca.200490280

Reference yield:

: 847153-40-6
(R)-4-{[(acetamido)methyl]thio}-1-diazo-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butan-2-one

: 646068-80-6
(R)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-[(triphenylmethyl)sulfanyl]butanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 3.2 g / acetonitrile; H₂O / 0 °C / Irradiation

2: Hg(OAc)2 / tetrahydrofuran; H₂O; acetic acid / 20 °C

3: 4.4 g / N-methylmorpholine / CHCl₃ / 15 h / 0 - 20 °C

With 4-methyl-morpholine; mercury(II) diacetate; In tetrahydrofuran; chloroform; water; acetic acid; acetonitrile;
DOI:10.1002/hlca.200490280