N-(2-Methylphenyl)piperidine

Base Information

• Chemical Name: N-(2-Methylphenyl)piperidine
• CAS No.: 7250-70-6
• Molecular Formula: C12H17N
• Molecular Weight: 175.274
• NSC Number: 30149
• DSSTox Substance ID: DTXSID50222816
• Nikkaji Number: J385.418C
• Wikidata: Q83101155
• Mol file: 7250-70-6.mol

Synonyms:1-(2-methylphenyl)piperidine;N-(2-Methylphenyl)piperidine;7250-70-6;1-(2-Methylphenyl)-Piperidine;1-o-tolylpiperidine;toluylpiperidine;NSC30149;SCHEMBL2332676;DTXSID50222816;OGLZSMPGMUDNKR-UHFFFAOYSA-N;Piperidine, 1-(2-methylphenyl)-;NSC 30149;NSC-30149;FT-0745556;A19098

Chemical Property of N-(2-Methylphenyl)piperidine

Chemical Property:

• Vapor Pressure: 0.0053mmHg at 25°C
• Boiling Point: 274.8°Cat760mmHg
• Flash Point: 109.7°C
• PSA: 3.24000
• Density: 0.984g/cm³
• LogP: 3.05030
• XLogP3: 3.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 175.136099547
• Heavy Atom Count: 13
• Complexity: 149

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=CC=C1N2CCCCC2

Technology Process of N-(2-Methylphenyl)piperidine

There total 18 articles about N-(2-Methylphenyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

piperidine (110-89-4) + 2-methylchlorobenzene (95-49-8) → 1-(2-methylphenyl)piperidine (7250-70-6)

Guidance literature:

With C₃₅H₄₄Cl₂N₄Pd; potassium tert-butylate; In tetrahydrofuran; at 130 ℃; for 12h; Inert atmosphere; Sealed tube;

DOI:10.1039/c6ra02556k

Reference yield: 97.0%

piperidine (110-89-4) + ortho-methylphenyl iodide (615-37-2) → 1-(2-methylphenyl)piperidine (7250-70-6)

Guidance literature:

With sodium t-butanolate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 1,3,5,7-tetramethyl-8-phenyl-2,4,6-trioxa-8-phosphatricyclo[3.3.1.13,7]decane; In toluene; at 30 ℃;

DOI:10.1016/j.tetlet.2004.09.067

Reference yield: 96.0%

piperidin-1-yl benzoate (5542-49-4) + bis(2-methylphenyl)zinc (7029-31-4) → 1-(2-methylphenyl)piperidine (7250-70-6)

Guidance literature:

With copper(I) trifluoromethanesulfonate benzene; In tetrahydrofuran; at 25 ℃; for 1h;

DOI:10.1021/ja049474e

upstream raw materials:

TETRAHYDROPYRANE

o-toluidine

1-(2-methylphenyl)-2,6-piperidinedione

Glutaraldehyde

Downstream raw materials:

C₁₉H₁₉NO₂

2-(o-formylphenyl)-1-phenylethanone

Refernces

• 1、 Xia, Qing,Li, Yufei,Cheng, Lan,Liang, Xin,Cao, Chenlin,Dai, Peng,Deng, Hongping,Zhang, Weihua,Wang, Qingmin. "Electron Donor-Acceptor Complex-Initiated Photochemical Cyanation for the Preparation of α-Amino Nitriles". supporting information. p. 9638 - 9643. Retrieved 2020/12/21.
• 2、 Ruffoni, Alessandro,Juliá, Fabio,Svejstrup, Thomas D.,McMillan, Alastair J.,Douglas, James J.,Leonori, Daniele. "Practical and regioselective amination of arenes using alkyl amines". . p. 426 - 433. Retrieved 2019/05/01.