4-hydroxy-5-Methyl-5-octylthiophen-2(5H)-one

Base Information

Chemical Name:4-hydroxy-5-Methyl-5-octylthiophen-2(5H)-one
CAS No.:646483-08-1
Molecular Formula:C13H22O2S
Molecular Weight:242.382
Hs Code.:
Mol file:646483-08-1.mol

Synonyms:4-HYDROXY-5-METHYL-5-OCTYLTHIOPHEN-2(5H)-ONE;(+/-)-4-hydroxy-5-methyl-5-octyl-5H-thiophen-2-one;5-hydroxy-2-methyl-2-octyl-3-thiophenone;2(5H)-Thiophenone,4-hydroxy-5-methyl-5-octyl;2-methyl-2-octyl-5-oxidanyl-thiophen-3-one;

Suppliers and Price of 4-hydroxy-5-Methyl-5-octylthiophen-2(5H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of 4-hydroxy-5-Methyl-5-octylthiophen-2(5H)-one

Chemical Property:

Boiling Point:353.5±42.0 °C(Predicted)
PKA:4.50±1.00(Predicted)
PSA：62.60000
Density:1.063±0.06 g/cm3(Predicted)
LogP:4.21100

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-hydroxy-5-Methyl-5-octylthiophen-2(5H)-one

There total 12 articles about 4-hydroxy-5-Methyl-5-octylthiophen-2(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 646483-06-9
(+/-)-2-acetylsulfanyl-2-methyldecanoic acid ethyl ester

: 646483-08-1,845877-55-6
(+/-)-4-hydroxy-5-methyl-5-octyl-5H-thiophen-2-one

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 - -5 ℃;
DOI:10.1021/jm049389h

Reference yield:

: 646483-06-9
(+/-)-2-acetylsulfanyl-2-methyldecanoic acid ethyl ester

: 646483-08-1,845877-55-6
(+/-)-4-hydroxy-5-methyl-5-octyl-5H-thiophen-2-one

: 5-methyl-5-octyl-thiophene-2,4-dione

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 - -5 ℃; for 2.33333h;

Reference yield:

: 71091-89-9
n-octyl triflate

: 646483-08-1,845877-55-6
(+/-)-4-hydroxy-5-methyl-5-octyl-5H-thiophen-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: LiHMDS / tetrahydrofuran / -78 °C

1.2: 81 percent / tetrahydrofuran / -78 °C

2.1: ethanol / 2 h / 20 °C

3.1: 725 mg / NEt₃ / CH₂Cl₂ / 0.67 h / 0 °C

4.1: 73 percent / LiHMDS / tetrahydrofuran / -78 - -5 °C

With triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; dichloromethane; 4.1: Dieckmann condensation;
DOI:10.1021/jm049389h