Technology Process of L-Proline, 5-[2-(1,1-dimethylethoxy)-2-oxoethylidene]-1-(phenylmethyl)-,
(4-nitrophenyl)methyl ester, (5E)-
There total 1 articles about L-Proline, 5-[2-(1,1-dimethylethoxy)-2-oxoethylidene]-1-(phenylmethyl)-,
(4-nitrophenyl)methyl ester, (5E)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
bromoacetic acid tert-butyl ester; (S)-1-Benzyl-5-thioxo-pyrrolidine-2-carboxylic acid 4-nitro-benzyl ester;
In
acetonitrile;
for 40h;
With
triethylamine; triphenylphosphine;
In
dichloromethane;
for 20h;
DOI:10.1021/ja037665w
- Guidance literature:
-
Multi-step reaction with 6 steps
1: sodium cyanoborohydride; acetic acid / acetonitrile
2: H2 / Pd(OH)2/C / ethanol / 48 h
3: t-BuOH / H2O
4: Cs2CO3 / dimethylformamide
5: TFA
6: N-methyl-2-chloropyridinium triflate; diisopropylethylamine / acetonitrile / 4 h
With
hydrogen; sodium cyanoborohydride; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-methyl-2-chloropyridinium trifluoromethanesulfonate; tert-butyl alcohol;
palladium dihydroxide;
In
ethanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ja037665w
- Guidance literature:
-
Multi-step reaction with 5 steps
1: sodium cyanoborohydride; acetic acid / acetonitrile
2: H2 / Pd(OH)2/C / ethanol / 48 h
3: t-BuOH / H2O
4: Cs2CO3 / dimethylformamide
5: TFA
With
hydrogen; sodium cyanoborohydride; caesium carbonate; acetic acid; trifluoroacetic acid; tert-butyl alcohol;
palladium dihydroxide;
In
ethanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ja037665w
