L-Alanine, N-(1-oxo-3-phenylpropyl)-L-valyl-, 2-[2-(1,1-dimethylethoxy)-2-oxoethyl]-2-[[(2S,3S)-3-[(ethylamino)carbon yl]oxiranyl]carbonyl]hydrazide

Base Information

Chemical Name:L-Alanine, N-(1-oxo-3-phenylpropyl)-L-valyl-, 2-[2-(1,1-dimethylethoxy)-2-oxoethyl]-2-[[(2S,3S)-3-[(ethylamino)carbon yl]oxiranyl]carbonyl]hydrazide
CAS No.:646532-05-0
Molecular Formula:C29H43N5O8
Molecular Weight:589.689
Hs Code.:

L-Alanine, N-(1-oxo-3-phenylpropyl)-L-valyl-,
2-[2-(1,1-dimethylethoxy)-2-oxoethyl]-2-[[(2S,3S)-3-[(ethylamino)carbon
yl]oxiranyl]carbonyl]hydrazide

Synonyms:

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Chemical Property of L-Alanine, N-(1-oxo-3-phenylpropyl)-L-valyl-, 2-[2-(1,1-dimethylethoxy)-2-oxoethyl]-2-[[(2S,3S)-3-[(ethylamino)carbon yl]oxiranyl]carbonyl]hydrazide

Chemical Property:

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MSDS Files:: SDS file from LookChem

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Technology Process of L-Alanine, N-(1-oxo-3-phenylpropyl)-L-valyl-, 2-[2-(1,1-dimethylethoxy)-2-oxoethyl]-2-[[(2S,3S)-3-[(ethylamino)carbon yl]oxiranyl]carbonyl]hydrazide

There total 5 articles about L-Alanine, N-(1-oxo-3-phenylpropyl)-L-valyl-, 2-[2-(1,1-dimethylethoxy)-2-oxoethyl]-2-[[(2S,3S)-3-[(ethylamino)carbon yl]oxiranyl]carbonyl]hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 646532-77-6
3-phenylpropanoyl-Val-Ala-NHNHCH₂COO-t-Bu

: 142759-58-8
(2S,3S)-3-(3-ethylcarbamoyl)oxirane-2-carboxylic acid

: 646532-05-0
(N-(3-ethylcarbamoyl-oxiranecarbonyl)-N'-{2-[3-methyl-2-(3-phenyl-propionylamino)-butyrylamino]-propionyl}-hydrazino)-acetic acid tert-butyl ester

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 16h;
DOI:10.1021/jm0305016

Reference yield:

: 5292-43-3
bromoacetic acid tert-butyl ester

: 646532-05-0
(N-(3-ethylcarbamoyl-oxiranecarbonyl)-N'-{2-[3-methyl-2-(3-phenyl-propionylamino)-butyrylamino]-propionyl}-hydrazino)-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 55 percent / 4-methylmorpholine / dimethylformamide / 20.5 h / -10 - 20 °C

2: 62 percent / 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide / 16 h / 20 °C

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide;
DOI:10.1021/jm0305016

Reference yield:

: 85541-17-9
(S)-2-[(S)-3-Methyl-2-(3-phenyl-propionylamino)-butyrylamino]-propionic acid methyl ester

: 646532-05-0
(N-(3-ethylcarbamoyl-oxiranecarbonyl)-N'-{2-[3-methyl-2-(3-phenyl-propionylamino)-butyrylamino]-propionyl}-hydrazino)-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / NH₂NH₂ / methanol / 16 h / 20 °C

2: 55 percent / 4-methylmorpholine / dimethylformamide / 20.5 h / -10 - 20 °C

3: 62 percent / 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide / 16 h / 20 °C

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; hydrazine; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm0305016