L-Threonine, N-[(phenylmethoxy)carbonyl]-L-isoleucyl-L-a-glutamyl-, 2-(1,1-dimethylethyl) ester, 3-[2-[2-(1,1-dimethylethoxy)-2-oxoethyl]-2-[[(2R,3R)-3-[(phenylmethoxy) carbonyl]oxiranyl]carbonyl]hydrazide]

Base Information

Chemical Name:L-Threonine, N-[(phenylmethoxy)carbonyl]-L-isoleucyl-L-a-glutamyl-, 2-(1,1-dimethylethyl) ester, 3-[2-[2-(1,1-dimethylethoxy)-2-oxoethyl]-2-[[(2R,3R)-3-[(phenylmethoxy) carbonyl]oxiranyl]carbonyl]hydrazide]
CAS No.:646532-34-5
Molecular Formula:C44H61N5O14
Molecular Weight:883.993
Hs Code.:

L-Threonine, N-[(phenylmethoxy)carbonyl]-L-isoleucyl-L-a-glutamyl-,
2-(1,1-dimethylethyl) ester,
3-[2-[2-(1,1-dimethylethoxy)-2-oxoethyl]-2-[[(2R,3R)-3-[(phenylmethoxy)
carbonyl]oxiranyl]carbonyl]hydrazide]

Synonyms:

Suppliers and Price of L-Threonine, N-[(phenylmethoxy)carbonyl]-L-isoleucyl-L-a-glutamyl-, 2-(1,1-dimethylethyl) ester, 3-[2-[2-(1,1-dimethylethoxy)-2-oxoethyl]-2-[[(2R,3R)-3-[(phenylmethoxy) carbonyl]oxiranyl]carbonyl]hydrazide]

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of L-Threonine, N-[(phenylmethoxy)carbonyl]-L-isoleucyl-L-a-glutamyl-, 2-(1,1-dimethylethyl) ester, 3-[2-[2-(1,1-dimethylethoxy)-2-oxoethyl]-2-[[(2R,3R)-3-[(phenylmethoxy) carbonyl]oxiranyl]carbonyl]hydrazide]

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of L-Threonine, N-[(phenylmethoxy)carbonyl]-L-isoleucyl-L-a-glutamyl-, 2-(1,1-dimethylethyl) ester, 3-[2-[2-(1,1-dimethylethoxy)-2-oxoethyl]-2-[[(2R,3R)-3-[(phenylmethoxy) carbonyl]oxiranyl]carbonyl]hydrazide]

There total 5 articles about L-Threonine, N-[(phenylmethoxy)carbonyl]-L-isoleucyl-L-a-glutamyl-, 2-(1,1-dimethylethyl) ester, 3-[2-[2-(1,1-dimethylethoxy)-2-oxoethyl]-2-[[(2R,3R)-3-[(phenylmethoxy) carbonyl]oxiranyl]carbonyl]hydrazide] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 646532-93-6
(2R,3R)-oxirane-2,3-dicarboxylic acid monobenzyl ester

: 646532-82-3
Cbz-Ile-Glu(O-t-Bu)-Thr-NHNHCH₂COO-t-Bu

: 646532-34-5
3-(N'-{2-[2-(2-benzyloxycarbonylamino-3-methyl-pentanoylamino)-4-tert-butoxycarbonyl-butyrylamino]-3-hydroxy-butyryl}-N-tert-butoxycarbonylmethyl-hydrazinocarbonyl)-oxirane-2-carboxylic acid benzyl ester

Guidance literature:: (2R,3R)-oxirane-2,3-dicarboxylic acid monobenzyl ester; With 4-methyl-morpholine; isobutyl chloroformate; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

Cbz-Ile-Glu(O-t-Bu)-Thr-NHNHCH₂COO-t-Bu; In N,N-dimethyl-formamide; at 0 - 20 ℃;
DOI:10.1021/jm0305016

Reference yield:

: 5292-43-3
bromoacetic acid tert-butyl ester

: 646532-34-5
3-(N'-{2-[2-(2-benzyloxycarbonylamino-3-methyl-pentanoylamino)-4-tert-butoxycarbonyl-butyrylamino]-3-hydroxy-butyryl}-N-tert-butoxycarbonylmethyl-hydrazinocarbonyl)-oxirane-2-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 26 percent / 4-methylmorpholine / dimethylformamide / 20.5 h / -10 - 20 °C

2.1: N-methylmorpholine; isobutyl chloroformate / dimethylformamide / 0.5 h / 0 °C

2.2: 37 percent / dimethylformamide / 0 - 20 °C

With 4-methyl-morpholine; isobutyl chloroformate; In N,N-dimethyl-formamide;
DOI:10.1021/jm0305016

Reference yield:

: 100-51-6,185532-71-2
benzyl alcohol

: 646532-34-5
3-(N'-{2-[2-(2-benzyloxycarbonylamino-3-methyl-pentanoylamino)-4-tert-butoxycarbonyl-butyrylamino]-3-hydroxy-butyryl}-N-tert-butoxycarbonylmethyl-hydrazinocarbonyl)-oxirane-2-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 4-(dimethylamino)pyridine / dimethylformamide / 15 h / 20 °C

2.1: N-methylmorpholine; isobutyl chloroformate / dimethylformamide / 0.5 h / 0 °C

2.2: 37 percent / dimethylformamide / 0 - 20 °C

With 4-methyl-morpholine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; isobutyl chloroformate; In N,N-dimethyl-formamide;
DOI:10.1021/jm0305016