L-Valine, N-[(phenylmethoxy)carbonyl]-L-a-aspartyl-L-a-glutamyl-, 1,2-bis(1,1-dimethylethyl) ester, 3-[2-[2-(1,1-dimethylethoxy)-2-oxoethyl]hydrazide]

Base Information

Chemical Name:L-Valine, N-[(phenylmethoxy)carbonyl]-L-a-aspartyl-L-a-glutamyl-, 1,2-bis(1,1-dimethylethyl) ester, 3-[2-[2-(1,1-dimethylethoxy)-2-oxoethyl]hydrazide]
CAS No.:646532-79-8
Molecular Formula:C36H57N5O11
Molecular Weight:735.875
Hs Code.:

L-Valine, N-[(phenylmethoxy)carbonyl]-L-a-aspartyl-L-a-glutamyl-,
1,2-bis(1,1-dimethylethyl) ester,
3-[2-[2-(1,1-dimethylethoxy)-2-oxoethyl]hydrazide]

Synonyms:

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Chemical Property of L-Valine, N-[(phenylmethoxy)carbonyl]-L-a-aspartyl-L-a-glutamyl-, 1,2-bis(1,1-dimethylethyl) ester, 3-[2-[2-(1,1-dimethylethoxy)-2-oxoethyl]hydrazide]

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MSDS Files:: SDS file from LookChem

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Technology Process of L-Valine, N-[(phenylmethoxy)carbonyl]-L-a-aspartyl-L-a-glutamyl-, 1,2-bis(1,1-dimethylethyl) ester, 3-[2-[2-(1,1-dimethylethoxy)-2-oxoethyl]hydrazide]

There total 2 articles about L-Valine, N-[(phenylmethoxy)carbonyl]-L-a-aspartyl-L-a-glutamyl-, 1,2-bis(1,1-dimethylethyl) ester, 3-[2-[2-(1,1-dimethylethoxy)-2-oxoethyl]hydrazide] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 5292-43-3
bromoacetic acid tert-butyl ester

: 646532-71-0
tert-butyl (S)-4-((S)-2-(((benzyloxy)carbonyl)amino)-4-(tert-butoxy)-4-oxobutanamido)-5-(((S)-1-hydrazinyl-3-methyl-1-oxobutan-2-yl)amino)-5-oxopentanoate

: 646532-79-8
tert-butyl (5S,8S,11S)-5–(2-(tert-butoxy)-2-oxoethyl)-8–(3-(tertbutoxy)-3-oxopropyl)-11-isopropyl-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13,14-pentaazahexadecan-16-oate

Guidance literature:: With 4-methyl-morpholine; In N,N-dimethyl-formamide; at -10 - 20 ℃; for 20.5h;
DOI:10.1021/jm0305016

Reference yield:

: methyl (5S,8S,11S)-5–(2-(tert-butoxy)-2-oxoethyl)-8–(3-(tert-butoxy)-3-oxopropyl)-11-isopropyl-3,6,9-trioxo-1-phenyl-2-oxa-4,7,10-triazadodecan-12-oate

: 646532-79-8
tert-butyl (5S,8S,11S)-5–(2-(tert-butoxy)-2-oxoethyl)-8–(3-(tertbutoxy)-3-oxopropyl)-11-isopropyl-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13,14-pentaazahexadecan-16-oate

Guidance literature:: Multi-step reaction with 2 steps

1: 56 percent / NH₂NH₂ / methanol / 16 h / 20 °C

2: 65 percent / 4-methylmorpholine / dimethylformamide / 20.5 h / -10 - 20 °C

With 4-methyl-morpholine; hydrazine; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm0305016

Reference yield: 68.0%

: 2459-05-4
(E)-4-ethoxy-4-oxobut-2-enoic acid

: 646532-79-8
tert-butyl (5S,8S,11S)-5–(2-(tert-butoxy)-2-oxoethyl)-8–(3-(tertbutoxy)-3-oxopropyl)-11-isopropyl-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13,14-pentaazahexadecan-16-oate

: 685543-79-7
3-(N'-{2-[2-(2-benzyloxycarbonylamino-3-tert-butoxycarbonyl-propionylamino)-4-tert-butoxycarbonyl-butyrylamino]-3-methyl-butyryl}-N-tert-butoxycarbonylmethyl-hydrazinocarbonyl)-acrylic acid ethyl ester

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; at 20 ℃; for 16h;
DOI:10.1021/jm049938j