L-Threonine, N-[(phenylmethoxy)carbonyl]-L-leucyl-L-a-glutamyl-, 2-(1,1-dimethylethyl) ester, 3-[2-[2-(1,1-dimethylethoxy)-2-oxoethyl]hydrazide]

Base Information

Chemical Name:L-Threonine, N-[(phenylmethoxy)carbonyl]-L-leucyl-L-a-glutamyl-, 2-(1,1-dimethylethyl) ester, 3-[2-[2-(1,1-dimethylethoxy)-2-oxoethyl]hydrazide]
CAS No.:646532-81-2
Molecular Formula:C33H53N5O10
Molecular Weight:679.811
Hs Code.:

L-Threonine, N-[(phenylmethoxy)carbonyl]-L-leucyl-L-a-glutamyl-,
2-(1,1-dimethylethyl) ester,
3-[2-[2-(1,1-dimethylethoxy)-2-oxoethyl]hydrazide]

Synonyms:

Suppliers and Price of L-Threonine, N-[(phenylmethoxy)carbonyl]-L-leucyl-L-a-glutamyl-, 2-(1,1-dimethylethyl) ester, 3-[2-[2-(1,1-dimethylethoxy)-2-oxoethyl]hydrazide]

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of L-Threonine, N-[(phenylmethoxy)carbonyl]-L-leucyl-L-a-glutamyl-, 2-(1,1-dimethylethyl) ester, 3-[2-[2-(1,1-dimethylethoxy)-2-oxoethyl]hydrazide]

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of L-Threonine, N-[(phenylmethoxy)carbonyl]-L-leucyl-L-a-glutamyl-, 2-(1,1-dimethylethyl) ester, 3-[2-[2-(1,1-dimethylethoxy)-2-oxoethyl]hydrazide]

There total 2 articles about L-Threonine, N-[(phenylmethoxy)carbonyl]-L-leucyl-L-a-glutamyl-, 2-(1,1-dimethylethyl) ester, 3-[2-[2-(1,1-dimethylethoxy)-2-oxoethyl]hydrazide] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 5292-43-3
bromoacetic acid tert-butyl ester

: 646532-72-1
Cbz-Leu-Glu(O-t-Bu)-Thr-NHNH₂

: 646532-81-2
Cbz-Leu-Glu(O-t-Bu)-Thr-NHNHCH₂COO-t-Bu

Guidance literature:: With 4-methyl-morpholine; In N,N-dimethyl-formamide; at 20 ℃; for 16h;
DOI:10.1021/jm049938j DOI:10.1021/jm0601405

Reference yield:

: (2S,3R)-2-[(S)-2-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-4-tert-butoxycarbonyl-butyrylamino]-3-hydroxy-butyric acid methyl ester

: 646532-81-2
Cbz-Leu-Glu(O-t-Bu)-Thr-NHNHCH₂COO-t-Bu

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / NH₂NH₂ / methanol / 16 h / 20 °C

2: 34 percent / 4-methylmorpholine / dimethylformamide / 20.5 h / -10 - 20 °C

With 4-methyl-morpholine; hydrazine; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm0305016

Reference yield: 85.0%

: 863647-71-6
(E)-4-(dibenzylamino)-4-oxobut-2-enoic acid

: 646532-81-2
Cbz-Leu-Glu(O-t-Bu)-Thr-NHNHCH₂COO-t-Bu

: C₅₁H₆₈N₆O₁₂

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 16h;
DOI:10.1021/jm0601405