5-Oxazolepropanal, 2-[(2S,3R)-3-(iodomethyl)-1-(triphenylmethyl)-2-aziridinyl]-b-methyl-

Base Information

Chemical Name:5-Oxazolepropanal, 2-[(2S,3R)-3-(iodomethyl)-1-(triphenylmethyl)-2-aziridinyl]-b-methyl-
CAS No.:647028-77-1
Molecular Formula:C29H27IN2O2
Molecular Weight:562.45
Hs Code.:

Synonyms:

Suppliers and Price of 5-Oxazolepropanal, 2-[(2S,3R)-3-(iodomethyl)-1-(triphenylmethyl)-2-aziridinyl]-b-methyl-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-Oxazolepropanal, 2-[(2S,3R)-3-(iodomethyl)-1-(triphenylmethyl)-2-aziridinyl]-b-methyl-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 5-Oxazolepropanal, 2-[(2S,3R)-3-(iodomethyl)-1-(triphenylmethyl)-2-aziridinyl]-b-methyl-

There total 10 articles about 5-Oxazolepropanal, 2-[(2S,3R)-3-(iodomethyl)-1-(triphenylmethyl)-2-aziridinyl]-b-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 647028-89-5
(2S,3R)-2-(5-[3-hydroxy-1-methylpropyl]oxazol-2-yl)-3-iodomethyl-1-tritylaziridine

: 647028-77-1
(2S,3R)-3-iodomethyl-2-(5-[1-methyl-3-oxopropyl]oxazol-2-yl)-1-tritylaziridine

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/ja030452m

Reference yield:

: 13515-76-9,116457-91-1,4465-44-5
methyl N-trityl-L-serinate

: 647028-77-1
(2S,3R)-3-iodomethyl-2-(5-[1-methyl-3-oxopropyl]oxazol-2-yl)-1-tritylaziridine

Guidance literature:: Multi-step reaction with 8 steps

1.1: 99 percent / NaH / dimethylformamide / 1 h / 0 °C

2.1: 95 percent / diisobutylaluminium hydride / toluene / 1 h / -78 °C

3.1: BH₃ / tetrahydrofuran / 1 h / 20 °C

3.2: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

3.3: tetrahydrofuran / 1.5 h / -78 °C

4.1: Ph₃P; diethyl azodicarboxylate / tetrahydrofuran / 18 h / 20 °C

5.1: zirconocene dichloride; n-BuLi / tetrahydrofuran; hexane / -78 - 20 °C

6.1: Ph₃P; diethyl azodicarboxylate; MeI / toluene / 2 h / 70 °C

7.1: TBAF / tetrahydrofuran / 2 h / 0 °C

8.1: Dess-Martin periodinane / CH₂Cl₂ / 2 h / 20 °C

With n-butyllithium; zirconocene dichloride; borane; tetrabutyl ammonium fluoride; sodium hydride; diisobutylaluminium hydride; Dess-Martin periodane; triphenylphosphine; diethylazodicarboxylate; methyl iodide; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; toluene; 4.1: Mitsunobu reaction / 6.1: Mitsunobu reaction / 8.1: Dess-Martin oxidation;
DOI:10.1021/ja030452m

Reference yield:

: 647028-80-6
(S)-methyl 3-(allyloxy)-2-(tritylamino)propanoate

: 647028-77-1
(2S,3R)-3-iodomethyl-2-(5-[1-methyl-3-oxopropyl]oxazol-2-yl)-1-tritylaziridine

Guidance literature:: Multi-step reaction with 7 steps

1.1: 95 percent / diisobutylaluminium hydride / toluene / 1 h / -78 °C

2.1: BH₃ / tetrahydrofuran / 1 h / 20 °C

2.2: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

2.3: tetrahydrofuran / 1.5 h / -78 °C

3.1: Ph₃P; diethyl azodicarboxylate / tetrahydrofuran / 18 h / 20 °C

4.1: zirconocene dichloride; n-BuLi / tetrahydrofuran; hexane / -78 - 20 °C

5.1: Ph₃P; diethyl azodicarboxylate; MeI / toluene / 2 h / 70 °C

6.1: TBAF / tetrahydrofuran / 2 h / 0 °C

7.1: Dess-Martin periodinane / CH₂Cl₂ / 2 h / 20 °C

With n-butyllithium; zirconocene dichloride; borane; tetrabutyl ammonium fluoride; diisobutylaluminium hydride; Dess-Martin periodane; triphenylphosphine; diethylazodicarboxylate; methyl iodide; In tetrahydrofuran; hexane; dichloromethane; toluene; 3.1: Mitsunobu reaction / 5.1: Mitsunobu reaction / 7.1: Dess-Martin oxidation;
DOI:10.1021/ja030452m