L-Phenylalanine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-4-iodo-, heptyl ester

Base Information

• Chemical Name: L-Phenylalanine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-4-iodo-, heptyl ester
• CAS No.: 647036-71-3
• Molecular Formula: C31H34INO4
• Molecular Weight: 611.52
• Mol file: 647036-71-3.mol

Synonyms:

Chemical Property of L-Phenylalanine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-4-iodo-, heptyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of L-Phenylalanine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-4-iodo-, heptyl ester

There total 1 articles about L-Phenylalanine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-4-iodo-, heptyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) + 4-iodo-L-phenylalanine heptyl ester → N-fluorenylmethoxycarbonyl-4-iodo-L-phenylalanine heptyl ester (647036-71-3)

Guidance literature:

4-iodo-L-phenylalanine heptyl ester; With sodium carbonate; at 0 ℃; for 0.25h;

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide; In 1,4-dioxane; water; at 20 ℃;

DOI:10.1055/s-2003-41416

Reference yield: 61.0%

1,5-anhydro-2-deoxy-4,6-O-bis(tert-butylsilylidene)-3-O-triisopropylsilyl-D-arabino-hex-1-enitol (262266-33-1) + N-fluorenylmethoxycarbonyl-4-iodo-L-phenylalanine heptyl ester (647036-71-3) → (S)-2-Amino-3-[4-((4aR,8R,8aR)-2,2-di-tert-butyl-8-triisopropylsilanyloxy-4,4a,8,8a-tetrahydro-1,3,5-trioxa-2-sila-naphthalen-6-yl)-phenyl]-propionic acid heptyl ester

Guidance literature:

1,5-anhydro-2-deoxy-4,6-O-bis(tert-butylsilylidene)-3-O-triisopropylsilyl-D-arabino-hex-1-enitol; With tert.-butyl lithium; In tetrahydrofuran; at 0 ℃; for 0.5h;

With zinc(II) chloride; In tetrahydrofuran; at 20 ℃; for 1h;

N-fluorenylmethoxycarbonyl-4-iodo-L-phenylalanine heptyl ester; With diisobutylaluminium hydride; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; N,N-dimethyl acetamide; at 20 ℃; for 5h;

DOI:10.1055/s-2003-41416

upstream raw materials:

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide