alpha-phenylphenylalanine

Base Information

• Chemical Name: alpha-phenylphenylalanine
• CAS No.: 6278-95-1
• Molecular Formula: C₁₅H₁₅NO₂
• Molecular Weight: 241.29
• Mol file: 6278-95-1.mol

Synonyms:

Chemical Property of alpha-phenylphenylalanine

Chemical Property:

• Vapor Pressure: 2.25E-06mmHg at 25°C
• Boiling Point: 377.6°Cat760mmHg
• Flash Point: 182.2°C
• Density: 1.214g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of alpha-phenylphenylalanine

There total 22 articles about alpha-phenylphenylalanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-benzyl-5-phenylimidazolidine-2,4-dione (4927-43-9) → 2-Amino-2,3-diphenyl-propionsaeure (56594-95-7,6278-95-1)

Guidance literature:

With barium dihydroxide; In water; at 160 - 180 ℃;

DOI:10.1039/jr9600002119

Reference yield:

C24H23NO3 → (R)-(+)-α-benzyl-α-phenylglycine (6278-95-1)

Guidance literature:

With sodium hydroxide; In water; at 120 ℃; for 68h;

DOI:10.1021/acs.joc.5b00868

Reference yield:

2-{[1-(4-Chloro-phenyl)-meth-(Z)-ylidene]-amino}-3-phenyl-propionic acid ethyl ester (117470-84-5) → 2-Amino-2,3-diphenyl-propionsaeure (56594-95-7,6278-95-1)

Guidance literature:

Multi-step reaction with 2 steps

1: dimethylformamide / Heating

2: 1.) HCl, 2.) propylene oxide / 1.) water, reflux, 1h, 2.) ethanol, reflux, 15 min

With hydrogenchloride; methyloxirane; In N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(00)99282-7

upstream raw materials:

5-benzyl-5-phenylimidazolidine-2,4-dione

2-{[1-(4-Chloro-phenyl)-meth-(Z)-ylidene]-amino}-3-phenyl-propionic acid ethyl ester

(3S,6S)-3-Benzyl-3,6-dihydro-6-isopropyl-5-methoxy-3-phenyl-1,4-oxazin-2-on

(3S,6S)-3-Benzyl-6-tert-butyl-3,6-dihydro-5-methoxy-3-phenyl-2H-1,4-oxazin-2-on

Refernces

• 1、 O'Donnell, Martin J.,Bennett, William D.,Jacobsen, William N.,Ma, You-an. "PHENYLATION OF AMINO ACID DERIVATIVES: A NEW ROUTE TO Α-PHENYL-Α-SUBSTITUTED AMINO ACIDS". . p. 3913 - 3914. Retrieved 2007/10/02.