1H-Indole-1-carboxylic acid, 3-[1,2,3,4-tetrahydro-4-oxo-1-[(phenylmethoxy)carbonyl]-2-pyridinyl]-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: 1H-Indole-1-carboxylic acid, 3-[1,2,3,4-tetrahydro-4-oxo-1-[(phenylmethoxy)carbonyl]-2-pyridinyl]-, 1,1-dimethylethyl ester
• CAS No.: 647841-93-8
• Molecular Formula: C₂₆H₂₆N₂O₅
• Molecular Weight: 446.503
• Mol file: 647841-93-8.mol

Synonyms:

Chemical Property of 1H-Indole-1-carboxylic acid, 3-[1,2,3,4-tetrahydro-4-oxo-1-[(phenylmethoxy)carbonyl]-2-pyridinyl]-, 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1H-Indole-1-carboxylic acid, 3-[1,2,3,4-tetrahydro-4-oxo-1-[(phenylmethoxy)carbonyl]-2-pyridinyl]-, 1,1-dimethylethyl ester

There total 1 articles about 1H-Indole-1-carboxylic acid, 3-[1,2,3,4-tetrahydro-4-oxo-1-[(phenylmethoxy)carbonyl]-2-pyridinyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

di-tert-butyl dicarbonate (24424-99-5) + 2-(1H-indol-3-yl)-4-oxo-3,4-dihydro-2H-pyridine-1-carboxylic acid benzyl ester (647841-92-7) → 3-(1-benzyloxycarbonyl-4-oxo-1,2,3,4-tetrahydro-pyridin-2-yl)-indole-1-carboxylic acid tert-butyl ester (647841-93-8)

Guidance literature:

With dmap;

DOI:10.1016/j.tetlet.2003.10.030

Reference yield:

N-(5-chloropyridin-2-yl)-1,1,1-trifluoro-N-[(trifluoromethyl)sulphonyl]methanesulphonamide (145100-51-2) + 3-(1-benzyloxycarbonyl-4-oxo-1,2,3,4-tetrahydro-pyridin-2-yl)-indole-1-carboxylic acid tert-butyl ester (647841-93-8) → 3-(1-benzyloxycarbonyl-4-trifluoromethanesulfonyloxy-1,2,5,6-tetrahydro-pyridin-2-yl)-indole-1-carboxylic acid tert-butyl ester (647841-96-1) + 3-(1-benzyloxycarbonyl-4-trifluoromethanesulfonyloxy-1,2,3,6-tetrahydro-pyridin-2-yl)-indole-1-carboxylic acid tert-butyl ester

Guidance literature:

3-(1-benzyloxycarbonyl-4-oxo-1,2,3,4-tetrahydro-pyridin-2-yl)-indole-1-carboxylic acid tert-butyl ester; With L-Selectride; In tetrahydrofuran; at -78 - 0 ℃; for 3h;

N-(5-chloropyridin-2-yl)-1,1,1-trifluoro-N-[(trifluoromethyl)sulphonyl]methanesulphonamide; In tetrahydrofuran; at 25 ℃; for 2h;

DOI:10.1016/j.tetlet.2003.10.030

upstream raw materials:

di-tert-butyl dicarbonate

2-(1H-indol-3-yl)-4-oxo-3,4-dihydro-2H-pyridine-1-carboxylic acid benzyl ester

Downstream raw materials:

3-(1-benzyloxycarbonyl-4-trifluoromethanesulfonyloxy-1,2,5,6-tetrahydro-pyridin-2-yl)-indole-1-carboxylic acid tert-butyl ester