1-Bromo-2-(bromomethyl)-4,5-difluorobenzene, alpha,2-Dibromo-4,5-difluorotoluene

Base Information

• Chemical Name: 1-Bromo-2-(bromomethyl)-4,5-difluorobenzene, alpha,2-Dibromo-4,5-difluorotoluene
• CAS No.: 647862-95-1
• Molecular Formula: C7H4Br2F2
• Molecular Weight: 285.914
• Hs Code.: 2903999090
• Mol file: 647862-95-1.mol

Synonyms:2-bromo-4,5-difluorobenzyl bromide;Benzene,1-bromo-2-(bromomethyl)-4,5-difluoro;1-bromo-2-bromomethyl-4,5-difluorobenzene;

Chemical Property of 1-Bromo-2-(bromomethyl)-4,5-difluorobenzene, alpha,2-Dibromo-4,5-difluorotoluene

Chemical Property:

• PSA: 0.00000
• LogP: 3.62220
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

2-Bromo-4,5-difluorobenzyl bromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Bromo-2-(bromomethyl)-4,5-difluorobenzene, alpha,2-Dibromo-4,5-difluorotoluene

There total 3 articles about 1-Bromo-2-(bromomethyl)-4,5-difluorobenzene, alpha,2-Dibromo-4,5-difluorotoluene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(2-bromo-4,5-difluorophenyl)methanol (476620-55-0) → 1-bromo-2-(bromomethyl)-4,5-difluorobenzene (647862-95-1)

Guidance literature:

With phosphorus tribromide; In dichloromethane; at 25 ℃; for 24h;

DOI:10.3987/com-07-s(w)54

Reference yield: 63.0%

1-bromo-4,5-difluoro-2-methylbenzene (875664-38-3) → 1-bromo-2-(bromomethyl)-4,5-difluorobenzene (647862-95-1)

Guidance literature:

With N-Bromosuccinimide; dibenzoyl peroxide; at 82 ℃; for 12h; Inert atmosphere;

DOI:10.1021/acs.orglett.0c00122

Reference yield:

2-bromo-4,5-difluorobenzoic acid (64695-84-7) → 1-bromo-2-(bromomethyl)-4,5-difluorobenzene (647862-95-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 3.5 h / 20 °C / Heating / reflux

1.2: 0.17 h / 20 °C

2.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 2 h / 0 °C

With carbon tetrabromide; triphenylphosphine; 1,1'-carbonyldiimidazole; In tetrahydrofuran; dichloromethane;

upstream raw materials:

(2-bromo-4,5-difluorophenyl)methanol

2-bromo-4,5-difluorobenzoic acid

1-bromo-4,5-difluoro-2-methylbenzene

Downstream raw materials:

(2-bromo-4,5-difluorophenyl)acetonitrile

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