N-[5-tert-butyl-4-({6-hydroxy-2-[2-(4-hydroxyphenyl)ethyl]-2-(1-methylethyl)-4-oxo-3,4-dihydro-2H-pyran-5-yl}sulfanyl)-2-methylphenyl]pyridine-2-sulfonamide

Base Information

Chemical Name:N-[5-tert-butyl-4-({6-hydroxy-2-[2-(4-hydroxyphenyl)ethyl]-2-(1-methylethyl)-4-oxo-3,4-dihydro-2H-pyran-5-yl}sulfanyl)-2-methylphenyl]pyridine-2-sulfonamide
CAS No.:263842-56-4
Molecular Formula:C₃₂H₃₈N₂O₆S₂
Molecular Weight:610.796
Hs Code.:

N-[5-tert-butyl-4-({6-hydroxy-2-[2-(4-hydroxyphenyl)ethyl]-2-(1-methylethyl)-4-oxo-3,4-dihydro-2H-pyran-5-yl}sulfanyl)-2-methylphenyl]pyridine-2-sulfonamide

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Chemical Property of N-[5-tert-butyl-4-({6-hydroxy-2-[2-(4-hydroxyphenyl)ethyl]-2-(1-methylethyl)-4-oxo-3,4-dihydro-2H-pyran-5-yl}sulfanyl)-2-methylphenyl]pyridine-2-sulfonamide

Chemical Property:

Vapor Pressure:2.22E-21mmHg at 25°C
Boiling Point:713.7°Cat760mmHg
Flash Point:385.4°C
Density:1.33g/cm³

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Technology Process of N-[5-tert-butyl-4-({6-hydroxy-2-[2-(4-hydroxyphenyl)ethyl]-2-(1-methylethyl)-4-oxo-3,4-dihydro-2H-pyran-5-yl}sulfanyl)-2-methylphenyl]pyridine-2-sulfonamide

There total 4 articles about N-[5-tert-butyl-4-({6-hydroxy-2-[2-(4-hydroxyphenyl)ethyl]-2-(1-methylethyl)-4-oxo-3,4-dihydro-2H-pyran-5-yl}sulfanyl)-2-methylphenyl]pyridine-2-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 207736-87-6
4-hydroxy-6-[2-(4-hydroxy-phenyl)ethyl]-6-isopropyl-5,6-dihydro-pyran-2-one

: 263843-17-0
toluene-4-thiosulfonic acid S-[2-tert-butyl-4-(2-pyridinesulfonylamino)-5-methylphenyl] ester

: 263842-56-4
Pyridine-2-sulfonic acid (5-tert-butyl-4-{4-hydroxy-6-[2-(4-hydroxy-phenyl)-ethyl]-6-isopropyl-2-oxo-5,6-dihydro-2H-pyran-3-ylsulfanyl}-2-methyl-phenyl)-amide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm990281p

Reference yield:

: 2637-34-5,73018-10-7
2-Sulfanylpyridine

: 263842-56-4
Pyridine-2-sulfonic acid (5-tert-butyl-4-{4-hydroxy-6-[2-(4-hydroxy-phenyl)-ethyl]-6-isopropyl-2-oxo-5,6-dihydro-2H-pyran-3-ylsulfanyl}-2-methyl-phenyl)-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 63 percent / Cl₂; H₂O / CCl₄ / 1 h / 0 °C

2: 78 percent / pyridine / CH₂Cl₂ / 20 °C

3: 68 percent / K₂CO₃ / dimethylformamide / 20 °C

With pyridine; water; chlorine; potassium carbonate; In tetrachloromethane; dichloromethane; N,N-dimethyl-formamide; 1: Oxidation / 2: Sulfonylation / 3: Substitution;
DOI:10.1021/jm990281p

Reference yield:

: 66715-65-9
pyridine-2-sulfonyl chloride

: 263842-56-4
Pyridine-2-sulfonic acid (5-tert-butyl-4-{4-hydroxy-6-[2-(4-hydroxy-phenyl)-ethyl]-6-isopropyl-2-oxo-5,6-dihydro-2H-pyran-3-ylsulfanyl}-2-methyl-phenyl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / pyridine / CH₂Cl₂ / 20 °C

2: 68 percent / K₂CO₃ / dimethylformamide / 20 °C

With pyridine; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide; 1: Sulfonylation / 2: Substitution;
DOI:10.1021/jm990281p