2,3-Dihydro-3-(4-bromophenyl)-alpha-methyl-2-oxo-5-benzofuranacetic acid methyl ester

Base Information

Chemical Name:2,3-Dihydro-3-(4-bromophenyl)-alpha-methyl-2-oxo-5-benzofuranacetic acid methyl ester
CAS No.:77143-66-9
Molecular Formula:C₁₈H₁₅BrO₄
Molecular Weight:375.219
Hs Code.:
DSSTox Substance ID:DTXSID40998396

Synonyms:BRN 4528248;2,3-Dihydro-3-(4-bromophenyl)-alpha-methyl-2-oxo-5-benzofuranacetic acid methyl ester;5-Benzofuranacetic acid, 2,3-dihydro-3-(4-bromophenyl)-alpha-methyl-2-oxo-, methyl ester;77143-66-9;C18H15BrO4;C18-H15-Br-O4;DTXSID40998396;LS-34859;Methyl 2-[3-(4-bromophenyl)-2-oxo-2,3-dihydro-1-benzofuran-5-yl]propanoate

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2,3-Dihydro-3-(4-bromophenyl)-alpha-methyl-2-oxo-5-benzofuranacetic acid methyl ester

Chemical Property:

Vapor Pressure:1.62E-07mmHg at 25°C
Boiling Point:427.6°C at 760 mmHg
Flash Point:212.4°C
Density:1.462g/cm³
XLogP3:4.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:374.01537
Heavy Atom Count:23
Complexity:458

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C1=CC2=C(C=C1)OC(=O)C2C3=CC=C(C=C3)Br)C(=O)OC

Technology Process of 2,3-Dihydro-3-(4-bromophenyl)-alpha-methyl-2-oxo-5-benzofuranacetic acid methyl ester

There total 2 articles about 2,3-Dihydro-3-(4-bromophenyl)-alpha-methyl-2-oxo-5-benzofuranacetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 77143-74-9
2-{4-[(4-Bromo-phenyl)-ethoxycarbonyl-methoxy]-phenyl}-propionic acid methyl ester

: 77143-66-9
2-[3-(4-Bromo-phenyl)-2-oxo-2,3-dihydro-benzofuran-5-yl]-propionic acid methyl ester

Guidance literature:: With sulfuric acid; for 24h; Ambient temperature;

Reference yield:

: 65784-33-0
methyl 2-(4-hydroxyphenyl)propanoate

: 77143-66-9
2-[3-(4-Bromo-phenyl)-2-oxo-2,3-dihydro-benzofuran-5-yl]-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1) Na / 1) toluene, reflux, 8 h, 2) reflux, 8 h

2: 51 percent / conc. H₂SO₄ / 24 h / Ambient temperature

With sulfuric acid; sodium;