tert-Butyl 2-fluoro-3-hydroxypropylcarbamate

Base Information

Chemical Name:tert-Butyl 2-fluoro-3-hydroxypropylcarbamate
CAS No.:648900-68-9
Molecular Formula:C8H16FNO3
Molecular Weight:193.218
Hs Code.:
DSSTox Substance ID:DTXSID50423588
Nikkaji Number:J1.865.692B
Mol file:648900-68-9.mol

Synonyms:648900-68-9;tert-Butyl 2-fluoro-3-hydroxypropylcarbamate;tert-butyl N-(2-fluoro-3-hydroxypropyl)carbamate;tert-butyl (2-fluoro-3-hydroxypropyl)carbamate;tert-Butyl2-fluoro-3-hydroxypropylcarbamate;3-(Boc-amino)-2-fluoro-1-propanol;((S)-2-Fluoro-3-hydroxy-propyl)-carbamic acid tert-butyl ester;SCHEMBL1814117;DTXSID50423588;MFCD22571459;AB85776;SB46191;SY267364;tert-butyl(2-fluoro-3-hydroxypropyl)carbamate;EN300-321757;rac-tert-butyl (2-fluoro-3-hydroxypropyl)carbamate;2-Fluoro-3-hydroxypropylcarbamic acid tert-butyl ester

Suppliers and Price of tert-Butyl 2-fluoro-3-hydroxypropylcarbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
tert-Butyl(2-fluoro-3-hydroxypropyl)carbamate 97%
1g
$ 804.00

AK Scientific
Tert-Butyl2-fluoro-3-hydroxypropylcarbamate
1g
$ 1113.00

Total 7 raw suppliers

Chemical Property of tert-Butyl 2-fluoro-3-hydroxypropylcarbamate

Chemical Property:

Boiling Point:313.2±32.0 °C(Predicted)
PKA:11.68±0.46(Predicted)
PSA：62.05000
Density:1.096±0.06 g/cm3(Predicted)
LogP:1.04590
XLogP3:0.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:193.11142153
Heavy Atom Count:13
Complexity:167

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl(2-fluoro-3-hydroxypropyl)carbamate 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NCC(CO)F

Technology Process of tert-Butyl 2-fluoro-3-hydroxypropylcarbamate

There total 4 articles about tert-Butyl 2-fluoro-3-hydroxypropylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: C₁₅H₂₂FNO₃

: 648900-68-9
tert-butyl 2-fluoro-3-hydroxypropylcarbamate

Guidance literature:: With 10 wt% Pd(OH)2 on carbon; hydrogen; In ethanol; ethyl acetate; at 20 ℃; for 2.5h;

Reference yield:

: 137618-48-5
tert-butyl N-(2,3-dihydroxypropyl)carbamate

: 648900-68-9
tert-butyl 2-fluoro-3-hydroxypropylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 0.25 h / 20 °C

1.2: 0 - 20 °C

2.1: triethylamine; (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane / 10 h / 0 - 20 °C

3.1: 10 wt% Pd(OH)2 on carbon; hydrogen / ethyl acetate; ethanol / 2.5 h / 20 °C

With 10 wt% Pd(OH)2 on carbon; hydrogen; sodium hydride; triethylamine; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 648900-68-9
tert-butyl 2-fluoro-3-hydroxypropylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / tert-butyl alcohol / 5 h / 0 - 20 °C

2.1: sodium hydride / tetrahydrofuran / 0.25 h / 20 °C

2.2: 0 - 20 °C

3.1: triethylamine; (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane / 10 h / 0 - 20 °C

4.1: 10 wt% Pd(OH)2 on carbon; hydrogen / ethyl acetate; ethanol / 2.5 h / 20 °C

With 10 wt% Pd(OH)2 on carbon; hydrogen; sodium hydride; triethylamine; sodium hydroxide; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; tert-butyl alcohol;