N-(4-hydroxynaphthalen-1-yl)-4-methylbenzenesulfonamide

Base Information

• Chemical Name: N-(4-hydroxynaphthalen-1-yl)-4-methylbenzenesulfonamide
• CAS No.: 64920-21-4
• Molecular Formula: C17H15NO3S
• Molecular Weight: 313.377
• DSSTox Substance ID: DTXSID60356777
• Wikidata: Q82136345
• ChEMBL ID: CHEMBL4166834
• Mol file: 64920-21-4.mol

Synonyms:64920-21-4;N-(4-hydroxynaphthalen-1-yl)-4-methylbenzenesulfonamide;PCMD-CC-MCM-218;Benzenesulfonamide, N-(4-hydroxy-1-naphthalenyl)-4-methyl-;PC-0599222;ST50774383;Oprea1_372656;Oprea1_557823;SCHEMBL808104;cid_832572;CHEMBL4166834;BDBM43307;DTXSID60356777;AKOS002306444;n-(4-hydroxy-1-naphthyl)-4-methylbenzenesulfonamide;N-(4-hydroxy-1-naphthyl)-4-methyl-benzenesulfonamide;4-methyl-N-(4-oxidanylnaphthalen-1-yl)benzenesulfonamide;N-(4-hydroxy-1-naphthalenyl)-4-methylbenzenesulfonamide;N-(4-hydroxynaphthalen-1-yl)-4-methylbenzene-1-sulfonamide

Chemical Property of N-(4-hydroxynaphthalen-1-yl)-4-methylbenzenesulfonamide

Chemical Property:

• XLogP3: 3.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 313.07726451
• Heavy Atom Count: 22
• Complexity: 465

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)S(=O)(=O)NC2=CC=C(C3=CC=CC=C32)O

Technology Process of N-(4-hydroxynaphthalen-1-yl)-4-methylbenzenesulfonamide

There total 6 articles about N-(4-hydroxynaphthalen-1-yl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

4-amino-1-naphthol (2834-90-4) + p-toluenesulfonyl chloride (98-59-9) → N-(4-hydroxy-naphthalen-1-yl)-4-methyl-benzenesulfonamide (64920-21-4)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 12h;

DOI:10.1016/j.bmcl.2016.08.069

Reference yield:

N-(2,3-dibromo-4-oxo-3,4-dihydro-2H-naphthalen-1-ylidene)-4-methyl-benzenesulfonamide (236739-37-0) → N-(4-hydroxy-naphthalen-1-yl)-4-methyl-benzenesulfonamide (64920-21-4)

Guidance literature:

With zinc; In acetic acid;

Reference yield:

1-Nitronaphthalene (86-57-7) → N-(4-hydroxy-naphthalen-1-yl)-4-methyl-benzenesulfonamide (64920-21-4)

Guidance literature:

Multi-step reaction with 3 steps

1: tert.-butylhydroperoxide; potassium hydroxide / dimethyl sulfoxide; water

2: palladium on activated charcoal; hydrogen / methanol

3: 5 h / 0 - 20 °C

With tert.-butylhydroperoxide; palladium on activated charcoal; hydrogen; potassium hydroxide; In methanol; water; dimethyl sulfoxide;

DOI:10.1016/j.bmc.2013.11.052

upstream raw materials:

N-(2,3-dibromo-4-oxo-3,4-dihydro-2H-naphthalen-1-ylidene)-4-methyl-benzenesulfonamide

4-amino-1-naphthol

p-toluenesulfonyl chloride

1-Nitronaphthalene

Downstream raw materials:

N-(3-chloro-4-oxonaphthalen-1(4H)-ylidene)-4-methyl benzenesulfonamide

2,3-Dichloro-N-p-tolylsulfonyl-1,4-naphthoquinonemonoimine

4-p-tolylsulfonylimino-2,2,3,3-tetrachloro-1,2,3,4-tetrahydronaphthalen-1-one

N-(3-bromo-4-hydroxynaphthalen-1-yl)-4-methylbenzenesulfonamide