1(3H)-Isobenzofuranone, 3-[(1R)-1-hydroxybutyl]-7-(phenylmethoxy)-, (3R)-

Base Information

Chemical Name:1(3H)-Isobenzofuranone, 3-[(1R)-1-hydroxybutyl]-7-(phenylmethoxy)-, (3R)-
CAS No.:649552-12-5
Molecular Formula:C19H20O4
Molecular Weight:312.365
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1(3H)-Isobenzofuranone, 3-[(1R)-1-hydroxybutyl]-7-(phenylmethoxy)-, (3R)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

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Technology Process of 1(3H)-Isobenzofuranone, 3-[(1R)-1-hydroxybutyl]-7-(phenylmethoxy)-, (3R)-

There total 5 articles about 1(3H)-Isobenzofuranone, 3-[(1R)-1-hydroxybutyl]-7-(phenylmethoxy)-, (3R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 649552-11-4
methyl 2-(E)-1-pentenyl-6-benzyloxybenzoate

: 649552-12-5
(3R,1'R)-3-(1'-hydroxybutyl)-7-benzyloxyphthalide

Guidance literature:: With methanesulfonamide; 1,4-bis(9-O-dihydroquinidine)phthalazine; In water; tert-butyl alcohol; at 4 ℃; for 87h;
DOI:10.1271/bbb.67.2240

Reference yield:

: 2150-45-0
methyl 2,6-dihydroxybenzoate

: 649552-12-5
(3R,1'R)-3-(1'-hydroxybutyl)-7-benzyloxyphthalide

Guidance literature:: Multi-step reaction with 4 steps

1: 48 percent / potassium carbonate; sodium iodide / dimethylformamide / 4.5 h / 0 - 20 °C

2: pyridine / 2 h / cooling

3: 1.55 g / potassium carbonate / tetrakis(triphenylphosphine)palladium⁽⁰⁾ / benzene; ethanol / 14 h / Heating

4: 92 percent / AD-mixβ(R); CH3SO2NH2 / 2-methyl-propan-2-ol; H2O / 87 h / 4 °C

With pyridine; methanesulfonamide; potassium carbonate; 1,4-bis(9-O-dihydroquinidine)phthalazine; sodium iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; N,N-dimethyl-formamide; tert-butyl alcohol; benzene; 3: Suzuki-Miyaura coupling;
DOI:10.1271/bbb.67.2240

Reference yield:

: 25983-51-1
2,6-bis(benzyloxy)benzoic acid methyl ester

: 649552-12-5
(3R,1'R)-3-(1'-hydroxybutyl)-7-benzyloxyphthalide

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / hydrogen / palladium on carbon / ethyl acetate / 0.5 h

2: 48 percent / potassium carbonate; sodium iodide / dimethylformamide / 4.5 h / 0 - 20 °C

3: pyridine / 2 h / cooling

4: 1.55 g / potassium carbonate / tetrakis(triphenylphosphine)palladium⁽⁰⁾ / benzene; ethanol / 14 h / Heating

5: 92 percent / AD-mixβ(R); CH3SO2NH2 / 2-methyl-propan-2-ol; H2O / 87 h / 4 °C

With pyridine; methanesulfonamide; hydrogen; potassium carbonate; 1,4-bis(9-O-dihydroquinidine)phthalazine; sodium iodide; palladium on activated charcoal; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; ethyl acetate; N,N-dimethyl-formamide; tert-butyl alcohol; benzene; 4: Suzuki-Miyaura coupling;
DOI:10.1271/bbb.67.2240