3-Methylquinolin-4-ol

Base Information

• Chemical Name: 3-Methylquinolin-4-ol
• CAS No.: 64965-46-4
• Molecular Formula: C10H9NO
• Molecular Weight: 159.188
• European Community (EC) Number: 858-133-2
• DSSTox Substance ID: DTXSID30464656
• Nikkaji Number: J1.875.492D
• Wikidata: Q82290072

Synonyms:3-methylquinolin-4-ol;64965-46-4;3-methyl-1H-quinolin-4-one;3-METHYL-4-QUINOLINOL;MFCD09264039;3-methylquinolin-4(1H)-one;4-Oxychinolin-3-carbon;SCHEMBL4488517;DTXSID30464656;MEBYZSAQFUZJEQ-UHFFFAOYSA-N;AC6544;AKOS006330692;AKOS015830672;AB50475;AS-57504;SY238243;BB 0263636;EN300-118437;A918265;Z1198219340

Chemical Property of 3-Methylquinolin-4-ol

Chemical Property:

• Melting Point: 323-324 °C
• Boiling Point: 319.5±22.0 °C(Predicted)
• PKA: 4.36±0.50(Predicted)
• Density: 1.210±0.06 g/cm3(Predicted)
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 159.068413911
• Heavy Atom Count: 12
• Complexity: 232

Purity/Quality:

97% ^*data from raw suppliers

3-Methylquinolin-4-ol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CNC2=CC=CC=C2C1=O

Technology Process of 3-Methylquinolin-4-ol

There total 7 articles about 3-Methylquinolin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

3-methylquinoline (612-58-8) → 3-methylquinolin-4-ol (64965-46-4)

Guidance literature:

With dihydrogen peroxide; acetic acid; at 60 ℃;

Reference yield:

4-hydroxy-3-methylquinoline-2-carboxylic acid (858488-66-1,402491-58-1) → 3-methylquinolin-4-ol (64965-46-4)

Guidance literature:

With mineral oil; at 270 - 280 ℃;

DOI:10.1021/ja01205a042

Reference yield:

4-hydroxy-3-methylquinoline-2-carboxylic acid ethyl ester (219949-95-8,402491-57-0) → 3-methylquinolin-4-ol (64965-46-4)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaOH / 2.5 h / Heating

2: 231 mg / diphenyl ether / 1 h / 250 °C

With sodium hydroxide; In diphenylether;

DOI:10.1021/jm060262x

upstream raw materials:

4-hydroxy-3-methylquinoline-2-carboxylic acid

N-(2-propionylphenyl)formamide

ethyl 2-formylpropionate

aniline

Downstream raw materials:

1,3-dimethylquinolin-4-one

4-chloro-3-methylquinoline

sulfotep

1-(O,O-Diethylphosphorothio)-3-methyl-4-oxo-1,4-dihydroquinoline

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