Technology Process of 2-Oxazolidinone,
3-[(2R,3S,4S,5S,6S,7Z)-3-hydroxy-2,4,6-trimethyl-1-oxo-5-[(triethylsilyl)
oxy]-7,9-decadienyl]-4-(phenylmethyl)-, (4R)-
There total 6 articles about 2-Oxazolidinone,
3-[(2R,3S,4S,5S,6S,7Z)-3-hydroxy-2,4,6-trimethyl-1-oxo-5-[(triethylsilyl)
oxy]-7,9-decadienyl]-4-(phenylmethyl)-, (4R)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(3R)-3-propionyl-4-benzyloxazolidin-2-one;
With
di-n-butylboryl trifluoromethanesulfonate; triethylamine;
In
dichloromethane;
at 0 ℃;
for 1h;
Inert atmosphere;
(Z)-(2R,3S,4S)-2,4-dimethyl-3-triethylsilanyloxyocta-5,7-dienal;
In
dichloromethane;
at -78 - 0 ℃;
for 0.75h;
DOI:10.1021/op049807s
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 0.67 h / -30 °C / Inert atmosphere
2.1: triethylamine; di-n-butylboryl trifluoromethanesulfonate / dichloromethane / 1 h / 0 °C / Inert atmosphere
2.2: 0.75 h / -78 - 0 °C
With
di-n-butylboryl trifluoromethanesulfonate; diisobutylaluminium hydride; triethylamine;
In
tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/op049807s
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: chromium dichloride / tetrahydrofuran / 4 h / 0 °C / Inert atmosphere
2.1: potassium hydride / tetrahydrofuran; mineral oil / 0 °C / Inert atmosphere
3.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 0.67 h / -30 °C / Inert atmosphere
4.1: triethylamine; di-n-butylboryl trifluoromethanesulfonate / dichloromethane / 1 h / 0 °C / Inert atmosphere
4.2: 0.75 h / -78 - 0 °C
With
chromium dichloride; di-n-butylboryl trifluoromethanesulfonate; potassium hydride; diisobutylaluminium hydride; triethylamine;
In
tetrahydrofuran; dichloromethane; toluene; mineral oil;
DOI:10.1021/op049807s
